Molecules, Systems and Signaling in Liver Injury

  • Wen-Xing Ding
  • Xiao-Ming Yin

Part of the Cell Death in Biology and Diseases book series (CELLDEATH)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Edward N. Harris, Justin L. Mott
    Pages 1-21
  3. April O’Brien, Chad Hall, Laurent Ehrlich, Tianhao Zhou, Fanyin Meng, Gianfranco Alpini et al.
    Pages 23-38
  4. Fatemeh P. Parvin-Nejad, Scott L. Friedman
    Pages 39-52
  5. Hayato Hikita, Tetsuo Takehara
    Pages 75-85
  6. Kari Nichole Nejak-Bowen, Satdarshan Pal Singh Monga
    Pages 87-132
  7. Rui Kang, Daolin Tang
    Pages 133-158
  8. Carl W. Decker, Joseph G. Casian, Kim Tho Nguyen, Luke A. Horton, Madhuri P. Rao, Kai H. Silkwood et al.
    Pages 159-181
  9. Kristina L. Go, Sooyeon Lee, Kevin E. Behrns, Jae-Sung Kim
    Pages 183-219
  10. Cheng Ji, Neil Kaplowitz, Hui Han
    Pages 221-250
  11. Wenke Feng, Craig McClain
    Pages 251-283
  12. Back Matter
    Pages 285-290

About this book


This essential volume presents comprehensive information on cell death and autophagy in liver diseases, including the role and molecular signaling pathways of cell death in alcohol and non-alcoholic fatty liver disease, bile acids, hepatitis C virus and drug-induced liver injury. The book starts with a discussion of lipotoxicity in non-parenchymal cells, followed by a discussion of cell death and autophagy in cholangiocytes, hepatic stellate cells and Kupffer cells in hepatic biliary diseases, fibrosis and liver inflammation. The book also covers Bcl-2 family proteins, beta-catenin and HMGB1 signaling in regulating cell death in the liver as well as mitochondria, ER stress and gut microbiota on liver injury. The Cell Death in Biology and Diseases series has recruited world experts ranging from basic scientists to clinicians on cell death in liver diseases. Likewise the contributors of this volume are leaders in their fields with worldwide expertise and perspective. Molecules, Systems and Signaling in Liver Injury is an essential companion to Hepatocytes and Non-Parenchymal Cells and Diseases. It is beneficial for both clinicians and basic scientists and is relevant to those working on drug discovery for preventing and treating liver diseases by targeting cell death and autophagy pathways.


mitophagy liver inflammation oncogenesis apoptosis liver cancer

Editors and affiliations

  • Wen-Xing Ding
    • 1
  • Xiao-Ming Yin
    • 2
  1. 1.Department of Pharmacology Toxicology and TherapyThe University of Kansas Medical CenterKansas CityUSA
  2. 2.Health Pathology LaboratoryIndiana UniversityIndianapolisUSA

Bibliographic information