The Structural Basis of Arrestin Functions

  • Vsevolod V. Gurevich

Table of contents

  1. Front Matter
    Pages i-ix
  2. Introduction

  3. Localization of Functional Elements on Arrestins

    1. Front Matter
      Pages 31-31
    2. Sungsoo M. Yoo, Dong Soo Kang, Jeffrey L. Benovic
      Pages 43-57
    3. Benjamin W. Spiller, Xuanzhi Zhan, Vsevolod V. Gurevich
      Pages 59-67
    4. Reuven Wiener, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich, Joel A. Hirsch
      Pages 69-82
    5. Raphael S. Haider, Aurélien Rizk, Gebhard F. X. Schertler, Martin K. Ostermaier
      Pages 83-102
    6. Martha E. Sommer
      Pages 103-118
    7. Ji Young Park, Hee Ryung Kim, Ka Young Chung
      Pages 119-132
    8. Sergey A. Vishnivetskiy, Wayne L. Hubbell, Candice S. Klug, Vsevolod V. Gurevich
      Pages 133-140
  4. Arrestin Flexibility and Activation

    1. Front Matter
      Pages 141-141
    2. Renu Batra-Safferling, Joachim Granzin
      Pages 143-158
    3. Abhishek Bandyopadhyay, Ya Zhuo, Wayne L. Hubbell, Candice S. Klug, Vsevolod V. Gurevich, Oliver P. Ernst
      Pages 159-173
    4. Yanyong Kang, Karsten Melcher, Vsevolod V. Gurevich, H. Eric Xu
      Pages 175-184
  5. Arrestin-Mediated Signaling and Biased Mutants

    1. Front Matter
      Pages 185-185
    2. Louis M. Luttrell, Benjamin W. Spiller
      Pages 199-217
    3. Zhao Yang, Fan Yang, Anthony Nguen, Chuan Liu, Amy Lin, Thomas Joseph Cahill III et al.
      Pages 219-234
    4. Carsten Hoffmann, Martin J. Lohse, Louis M. Luttrell
      Pages 235-253
    5. Nicole A. Perry, Xuanzhi Zhan, T. M. Iverson, Eugenia V. Gurevich, Vsevolod V. Gurevich
      Pages 255-271
    6. Sandra Berndt, Vsevolod V. Gurevich, Eugenia V. Gurevich
      Pages 273-302
  6. Back Matter
    Pages 303-304

About this book


This volume summarizes our current understanding of the structural basis of the functions of arrestin family of proteins. Arrestins were first discovered as key players in the desensitization of G protein-coupled receptors (GPCRs). Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death.

Here arrestin functions are described primarily from the structural prospective. The book covers basal structure of arrestin proteins, receptor binding-induced conformational changes in arrestins, as well as the structure of “pre-activated” mutants. Particular focus is on the arrestin elements interacting with numerous binding partners, GPCRs and cytoplasmic signaling proteins. We expect that this information and insights will help to understand and exploit the phenomenon of signaling bias, which is a new promising direction in drug discovery.

The chapters are written by the world-class specialists in the field, mostly the people who actually contributed the data discussed. The book gives coherent historical prospective and describes the most recent findings.

The book would be particularly useful for scientists in academia and industry working in the fields of pharmacology, cell biology, structural biology, and drug discovery. We expect that the focus on the molecular basis of protein-protein interactions would help to develop novel tools for engaging this important type of targets for research and therapeutic purposes.


GPCR Cell Signalling Protein Structure Redesigning Signalling Proteins

Editors and affiliations

  • Vsevolod V. Gurevich
    • 1
  1. 1.Department of PharmacologyVanderbilt UniversityNashvilleUSA

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