Patient-Derived Mouse Models of Cancer

Patient-Derived Orthotopic Xenografts (PDOX)

  • Robert M. Hoffman

Part of the Molecular and Translational Medicine book series (MOLEMED)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Sun-Jin Kim, Ho Jeong Lee, Hyunkyung Yu, Sung II Choi, John Weinstein, Jing Wang et al.
    Pages 55-69
  3. R. B. Marques, C. M. A. de Ridder, W. M. van Weerden
    Pages 89-112
  4. Tara A. Russell, Irmina A. Elliott, Arun S. Singh, Fritz C. Eilber
    Pages 113-124
  5. Robert M. Hoffman, Yukihiko Hiroshima, Takashi Murakami, Takuya Murata
    Pages 125-132
  6. Marta Paez-Ribes, Raquel Munoz, Eric Guerin, Shan Man, Ping Xu, John Ebos et al.
    Pages 161-182
  7. Robert M. Hoffman, Atsushi Suetsugu, Tasuku Kiyuna, Shuya Yano, Michael Bouvet
    Pages 207-216
  8. Robert M. Hoffman, Yukihiko Hiroshima, Shuya Yano, Cristina A. Metildi, Michael Bouvet
    Pages 217-226
  9. Vincent Vuaroqueaux, Anne-Lise Peille, Bruno Zeitouni, Anne-Marie Eades-Perner, Heinz-Herbert Fiebig
    Pages 227-243
  10. Robert M. Hoffman, Takashi Murakami, Kei Kawaguchi, Arun S. Singh, Fritz C. Eilber
    Pages 245-250
  11. David M. Evans, Beverly A. Teicher
    Pages 251-275
  12. Back Matter
    Pages 291-296

About this book


This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section.

Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems


immunodeficient mice The SCID mouse Surgical orthotopic implantation Transgenic nude mice orthotopic models

Editors and affiliations

  • Robert M. Hoffman
    • 1
  1. 1.University of California and AntiCancer Inc.San DiegoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-57423-3
  • Online ISBN 978-3-319-57424-0
  • Series Print ISSN 2197-7852
  • Series Online ISSN 2197-7860
  • Buy this book on publisher's site