Computer-Aided Design of Microfluidic Very Large Scale Integration (mVLSI) Biochips

Design Automation, Testing, and Design-for-Testability

  • Kai Hu
  • Krishnendu Chakrabarty
  • Tsung-Yi Ho

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Kai Hu, Krishnendu Chakrabarty, Tsung-Yi Ho
    Pages 1-24
  3. Kai Hu, Krishnendu Chakrabarty, Tsung-Yi Ho
    Pages 25-52
  4. Kai Hu, Krishnendu Chakrabarty, Tsung-Yi Ho
    Pages 53-79
  5. Kai Hu, Krishnendu Chakrabarty, Tsung-Yi Ho
    Pages 81-115
  6. Kai Hu, Krishnendu Chakrabarty, Tsung-Yi Ho
    Pages 117-136
  7. Kai Hu, Krishnendu Chakrabarty, Tsung-Yi Ho
    Pages 137-140
  8. Back Matter
    Pages 141-142

About this book


This book provides a comprehensive overview of flow-based, microfluidic VLSI. The authors describe and solve in a comprehensive and holistic manner practical challenges such as control synthesis, wash optimization, design for testability, and diagnosis of modern flow-based microfluidic biochips. They introduce practical solutions, based on rigorous optimization and formal models. The technical contributions presented in this book will not only shorten the product development cycle, but also accelerate the adoption and further development of modern flow-based microfluidic biochips, by facilitating the full exploitation of design complexities that are possible with current fabrication techniques.

  • Offers the first practical problem formulation for automated control-layer design in flow-based microfluidic biochips and provides a systematic approach for solving this problem;
  • Introduces a wash-optimization method for cross-contamination removal;
  • Presents a design-for-testability (DfT) technique that can achieve 100% fault coverage at the logic level, i.e., complete defect coverage for all valves and microchannels;
  • Includes a method for fault diagnosis in flow-based microfluidic biochips, which detects leakage and blockage defects in both control and flow layers.


Digital Microfluidic Biochips Microfluidics Based Microsystems Microfluidic Very Large Scale Integration design-for-testability in digital microfluidic biochips Fault-Tolerant Digital Microfluidic Biochips

Authors and affiliations

  • Kai Hu
    • 1
  • Krishnendu Chakrabarty
    • 2
  • Tsung-Yi Ho
    • 3
  1. 1.Oracle, Inc. Santa ClaraUSA
  2. 2.Department of ECEDuke University Department of ECEDurhamUSA
  3. 3.Department of Computer ScienceNational Tsing Hua University Department of Computer ScienceHsinchuTaiwan

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Engineering
  • Print ISBN 978-3-319-56254-4
  • Online ISBN 978-3-319-56255-1
  • Buy this book on publisher's site