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Essential and Non-essential Metals

Carcinogenesis, Prevention and Cancer Therapeutics

  • Anuradha Mudipalli
  • Judith T. Zelikoff

Part of the Molecular and Integrative Toxicology book series (MOLECUL)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Valentina Trapani, Federica I. Wolf
    Pages 19-38
  3. Xiangrong Geng, Liu Liu, Kan-Jen Tsai, Zijuan Liu
    Pages 39-68
  4. Jenna Guynn, Elizabeth A. W. Chan
    Pages 69-94
  5. J. Christopher States
    Pages 95-111
  6. Anuradha Mudipalli
    Pages 113-142
  7. Cynthia L. Browning, Rachel M. Speer, John Pierce Wise Sr.
    Pages 143-180
  8. Qiao Yi Chen, Jason Brocato, Freda Laulicht, Max Costa
    Pages 181-197
  9. Back Matter
    Pages 223-228

About this book

Introduction

This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.

Keywords

Cancer Carcinogen Metal Molecular medicine Treatment

Editors and affiliations

  • Anuradha Mudipalli
    • 1
  • Judith T. Zelikoff
    • 2
  1. 1.Natl Ctr Envtl Assessment Office of Res and DevtResearch Triangle ParkUSA
  2. 2.Professor of Environmental MedicineNew York UniversityTuxedoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-55448-8
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-55446-4
  • Online ISBN 978-3-319-55448-8
  • Series Print ISSN 2168-4219
  • Series Online ISSN 2168-4235
  • Buy this book on publisher's site