Antiphospholipid Syndrome

Current Research Highlights and Clinical Insights

  • Doruk Erkan
  • Michael D. Lockshin

Table of contents

  1. Front Matter
    Pages i-xx
  2. Historical Aspects of Antiphospholipid Syndrome

    1. Front Matter
      Pages 1-1
    2. Michael D. Lockshin, E. Nigel Harris
      Pages 3-11
  3. Basic Science Aspects of Antiphospholipid Syndrome

    1. Front Matter
      Pages 13-13
    2. Philip G. de Groot, Bas de Laat, Jacob Rand, Panayiotis G. Vlachoyiannopoulos, Fatima El-Assaad, Steven A. Krilis et al.
      Pages 15-27
    3. Joyce Rauch, Miri Blank, Philip G. de Groot, Kathryn M. Dupnik, Martin Alexander Kriegel, Jerrold S. Levine et al.
      Pages 29-52
    4. Rohan Willis, Hannah Cohen, Ian Giles, Jason S. Knight, Steven A. Krilis, Anisur Rahman et al.
      Pages 77-116
    5. Jane E. Salmon, Chieko Mineo, Ian Giles, Larry W. Chamley, Pier Luigi Meroni, Vikki M. Abrahams
      Pages 117-143
  4. Clinical and Diagnostic Aspects of Antiphospholipid Syndrome

    1. Front Matter
      Pages 145-145
    2. Ozan Unlu, Vinicius Domingues, Guilherme Ramires de Jesús, Stéphane Zuily, Gerard Espinosa, Ricard Cervera et al.
      Pages 147-169
    3. Maria Laura Bertolaccini, Olga Amengual, Bahar Artim-Eser, Tatsuya Atsumi, Philip G. de Groot, Bas de Laat et al.
      Pages 171-187
    4. Mary-Carmen Amigo, Kenji Oku, Savino Sciascia, María Victoria Goycochea Robles, Stéphane Zuily, Olga Amengual et al.
      Pages 189-199
    5. Cécile M. Yelnik, Simone Appenzeller, Giovanni Sanna, Elizabeth Kozora, Maria Laura Bertolaccini
      Pages 201-219
  5. Therapeutic Aspects of Antiphospholipid Syndrome

    1. Front Matter
      Pages 221-221
    2. Mark Crowther, Kimberly J. Legault, David A. Garcia, Maria G. Tektonidou, Amaia Ugarte, Ian N. Bruce et al.
      Pages 223-233
    3. Guilherme Ramires de Jesús, Karen J. Gibbins, Robert M. Silver, D. Ware Branch
      Pages 235-246
    4. Michelle Remião Ugolini-Lopes, Paulo Ricardo Criado, Kurosh Parsi, Reyhan Diz Kucukkaya, Mary-Carmen Amigo, Maria G. Tektonidou et al.
      Pages 247-266
    5. Medha Barbhaiya, Danieli Andrade, Maria Laura Bertolaccini, Doruk Erkan
      Pages 267-276
  6. 15th International Congress on Antiphospholipid Antibodies Task Force Reports

    1. Front Matter
      Pages 277-277
    2. Stéphane Zuily, Medha Barbhaiya, Karen H. Costenbader, Doruk Erkan
      Pages 279-290
    3. Arzu Soybilgic, Cassyanne L. Aguiar, M. Patricia Massicotte, Gili Kenet, E. Ann Yeh, Laura Andreoli et al.
      Pages 291-306
    4. Ricard Cervera, Ignasi Rodríguez Pintó, Gerard Espinosa, Tamir Shragai, Miri Blank, Yehuda Shoenfeld et al.
      Pages 307-316
    5. Danieli Andrade, Ricard Cervera, Hannah Cohen, Mark Crowther, Maria J. Cuadrado, Guillaume Canaud et al.
      Pages 317-338
  7. Antiphospholipid Syndrome for Patients

    1. Front Matter
      Pages 339-339
    2. Doruk Erkan, Ozan Unlu, Lindsay Lally, Michael D. Lockshin
      Pages 341-357
    3. Lisa R. Sammaritano, Roger Abramino Levy
      Pages 359-367
  8. Back Matter
    Pages 369-371

About this book


This new edition is a comprehensive and updated resource on antiphospholipid syndrome (APS), which is an autoimmune disorder. In APS, the body recognizes certain normal components of blood and/or cell membranes as foreign substances and produces antibodies (antiphospholipid antibodies) against them. APS is associated with recurrent clotting events (thrombosis) including premature stroke, repeated miscarriages, phlebitis, venous thrombosis, and pulmonary thromboembolism. It is also associated with low platelet or blood elements that prevent bleeding. Recently, however, even more disease states have been linked with APS, including premature heart attack, various cardiac valvular abnormalities, skin lesions, kidney disease, abnormal involuntary movement/chorea, diseases that mimic multiple sclerosis, and vascular diseases of the eye that can lead to visual loss and blindness. The International Congress on Antiphospholipid Antibodies, held every 3 years, is the venue where representatives from different disciplines gather to discuss the recent advances in APS. The conference intends to cover basic aspects of APS, such as pathogenesis, origins, genetics, intracellular and molecular events, the role of infections, as well as traditional and non-traditional clinical manifestations associated with antiphospholipid antibodies. The 15th Congress took place in September 2016. A novel aspect of the Congress was that multiple teams, chaired by Scientific Planning Committee members, used evidence-based literature reviews and expert discussions to answer specific pre-defined APS-related questions. These teams included points of view from experts in rheumatology, hematology, cardiovascular medicine, obstetrics, neurology, and immunology. The Scientific Planning Committee members also chaired the congress sessions and supervised completion of the reports that are the bases of the chapters of this book. In addition, there are two chapters included specifically written for APS patients. Much like the previous volume, dedicated to the 13th International Congress on Antiphospholipid Antibodies (April 2010), this up-to-date and comprehensive work gathers invaluable insights from a multidisciplinary team of world-renowned experts and represents the authoritative resource on causes, symptoms, diagnosis, and treatment of APS.​​


antiphospholipid antibody antiphospholipid syndrome autoimmune disorder obstetric antiphospholipid syndrome pulmonary thromboembolism thrombosis

Editors and affiliations

  • Doruk Erkan
    • 1
  • Michael D. Lockshin
    • 2
  1. 1.The Barbara Volcker Center for Women and Rheumatic Diseases, Associate Attending PhysicianHospital for Special Surgery, Associate Professor of Medicine, Weill Cornell MedicineNew YorkUSA
  2. 2.The Barbara Volcker Center for Women and Rheumatic Diseases, Attending PhysicianHospital for Special Surgery, Professor of Medicine and Obstetrics-Gynecology, Weill Cornell MedicineNew YorkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-55440-2
  • Online ISBN 978-3-319-55442-6
  • Buy this book on publisher's site