© 2018

Haploidentical Transplantation

Concepts & Clinical Application

  • Stefan O. Ciurea
  • Rupert Handgretinger

Table of contents

  1. Front Matter
    Pages i-xi
  2. Massimo F. Martelli, Yair Reisner, Richard E. Champlin
    Pages 1-11
  3. Graft Manipulation and Methods to Control T-cell Alloreactivity

  4. Ideal Graft and Donor

  5. Disease-Specific Pediatric Population

    1. Front Matter
      Pages 173-173
    2. Christian Seitz, Patrick Schlegel, Rupert Handgretinger
      Pages 175-194
  6. Disease-Specific Adult Population

    1. Front Matter
      Pages 217-217
    2. Vijaya Raj Bhatt, Stefan O. Ciurea
      Pages 231-243

About this book


In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty.


Haploidentical Transplantation T-Cell Alloreactivity Myeloablative Conditioning Regimen Non-Myeloablative Condtioning Regimen Immunologic Reconstitution

Editors and affiliations

  • Stefan O. Ciurea
    • 1
  • Rupert Handgretinger
    • 2
  1. 1.Department of Stem Cell TransplantationMD Anderson Cancer CenterHoustonUSA
  2. 2.Department of General Pediatrics and Hematology/OncologyUniversity Children’s HospitalTübingenGermany

About the editors

Stefan Ciurea is Associate Professor in the Department of Stem Cell Transplantation and Cellular Therapy at the University of Texas MD Anderson Cancer Center and leader of the Haploidentical Transplant Program at this institution. Dr. Ciurea received his medical degree from the Gr. T Popa University of Medicine and Pharmacy Iasi, Romania, and had Internal Medicine training at Harrisburg Hospital/PennState University, Fellowship in Hematology/Oncology at the University of Illinois at Chicago and Fellowship in Hematopoietic Stem Cell Transplantation and the University of Texas MD Anderson Cancer Center. He developed a Haploidentical Transplant Program at this institution with the goal to expand safe transplantation to all patients in need. Dr. Ciurea has made significant contributions in this field, primarily in identifying HLA antibodies as major cause of graft failure in mismatched transplantation and improving outcomes for patients with myeloid malignancies treated with hapl

oidentical transplantation, and is principal investigator on multiple clinical trials.

Rupert Handgretinger is Professor of Pediatrics, Chairman of the Department of General Pediatrics and Hematology/Oncology and Medical Director of the Children’s University Hospital Tübingen. He received his medical degree from the Eberhard-Karls-University in Tübingen in 1986 and was trained at the Children's University Hospital Tübingen in General Pediatrics and  Hematology/Oncology. In 2000,  he was appointed as director of the Division of Stem Cell Transplantation at St. Jude Children’s Research Hospital in Memphis, USA, where he served as a full faculty member and Professor of Pediatrics at the University of Tennessee, Memphis, until 2005. He returned to Tübingen in 2005 when he was appointed as Chairman of the Department of General Pediatrics and Hematology/Oncology at the Children's University Hospital Tübingen. His main research interests are cellular im

munotherapeutic approaches to the treatment of children with various forms of cancer in the context of allogeneic stem cell transplantation. He is especially interested in the  establishment of graft engineering techniques to introduce new concepts in haploidentical transplantation and in the elucidation of mechanisms of graft-mediated anti-tumor effects induced by Natural Killer and other effector cells.

Bibliographic information

  • Book Title Haploidentical Transplantation
  • Book Subtitle Concepts & Clinical Application
  • Editors Stefan O. Ciurea
    Rupert Handgretinger
  • Series Title Advances and Controversies in Hematopoietic Transplantation and Cell Therapy
  • Series Abbreviated Title Advances and Controversies in Hematopoietic Transplantation and Cell Therapy
  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-54309-3
  • Softcover ISBN 978-3-030-09611-3
  • eBook ISBN 978-3-319-54310-9
  • Edition Number 1
  • Number of Pages XI, 337
  • Number of Illustrations 7 b/w illustrations, 18 illustrations in colour
  • Topics Hematology
  • Buy this book on publisher's site