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© 2017

Neuroepigenomics in Aging and Disease

  • Raul Delgado-Morales
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 978)

Also part of the Proteomics, Metabolomics, Interactomics and Systems Biology book sub series (PMISB, volume 978)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Neurodevelopmental and Childhood Disorders

    1. Front Matter
      Pages 1-1
    2. Michelle T. Siu, Rosanna Weksberg
      Pages 63-90
  3. Adolescence Brain Diseases

    1. Front Matter
      Pages 91-91
    2. Lea Thaler, Howard Steiger
      Pages 93-103
    3. Amber N. Brown, Jian Feng
      Pages 105-125
    4. Hee-Dae Kim, Tanessa Call, Samantha Magazu, Deveroux Ferguson
      Pages 127-143
    5. Andrew A. Bartlett, Rumani Singh, Richard G. Hunter
      Pages 145-166
  4. Brain Disorders During Adulthood

    1. Front Matter
      Pages 167-167
    2. Ehsan Pishva, Bart P. F. Rutten, Daniel van den Hove
      Pages 185-196
    3. Rixing Lin, Gustavo Turecki
      Pages 197-210
    4. Lotta-Katrin Pries, Sinan Gülöksüz, Gunter Kenis
      Pages 211-236
    5. Alba Jimenez-Pacheco, Jaime M. Franco, Soledad Lopez, Juan Miguel Gomez-Zumaquero, Maria Magdalena Leal-Lasarte, Diana E. Caballero-Hernandez et al.
      Pages 255-275
    6. Silvia Bassi, Takshashila Tripathi, Alan Monziani, Francesca Di Leva, Marta Biagioli
      Pages 277-299
  5. Elderly Disorders

    1. Front Matter
      Pages 301-301

About this book

Introduction

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease).

The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

Keywords

epigenomics genomics Neurodegenerative Diseases microRNAs modifications

Editors and affiliations

  • Raul Delgado-Morales
    • 1
  1. 1.Cancer Epigenetics and Biology Program (PEBC)Bellvitge Biomedical Research Institute (IDIBELL)CATALONIASpain

About the editors

Raúl Delgado-Morales holds a PhD in Neuroscience. He completed his doctoral studies at the Universitat Autònoma de Barcelona working on the field of epigenetics on depression. He continued his research as a postdoc at the Max Planck Institute of Psychiatry in Munich. Dr. Delgado-Morales currently works as a postdoctoral researcher at the Bellvitge Biomedical Research Institute (IDIBELL), in Barcelona, Spain in the field of neuroepigenomics.

Bibliographic information

  • Book Title Neuroepigenomics in Aging and Disease
  • Editors Raul Delgado-Morales
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI https://doi.org/10.1007/978-3-319-53889-1
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-53888-4
  • Softcover ISBN 978-3-319-85266-9
  • eBook ISBN 978-3-319-53889-1
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XIII, 525
  • Number of Illustrations 2 b/w illustrations, 39 illustrations in colour
  • Topics Proteomics
    Gene Expression
    Gene Function
  • Buy this book on publisher's site