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Neuroepigenomics in Aging and Disease

  • Raul Delgado-Morales

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 978)

Also part of the Proteomics, Metabolomics, Interactomics and Systems Biology book sub series (PMISB, volume 978)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Neurodevelopmental and Childhood Disorders

    1. Front Matter
      Pages 1-1
    2. Michelle T. Siu, Rosanna Weksberg
      Pages 63-90
  3. Adolescence Brain Diseases

    1. Front Matter
      Pages 91-91
    2. Lea Thaler, Howard Steiger
      Pages 93-103
    3. Amber N. Brown, Jian Feng
      Pages 105-125
    4. Hee-Dae Kim, Tanessa Call, Samantha Magazu, Deveroux Ferguson
      Pages 127-143
    5. Andrew A. Bartlett, Rumani Singh, Richard G. Hunter
      Pages 145-166
  4. Brain Disorders During Adulthood

    1. Front Matter
      Pages 167-167
    2. Ehsan Pishva, Bart P. F. Rutten, Daniel van den Hove
      Pages 185-196
    3. Rixing Lin, Gustavo Turecki
      Pages 197-210
    4. Lotta-Katrin Pries, Sinan Gülöksüz, Gunter Kenis
      Pages 211-236
    5. Alba Jimenez-Pacheco, Jaime M. Franco, Soledad Lopez, Juan Miguel Gomez-Zumaquero, Maria Magdalena Leal-Lasarte, Diana E. Caballero-Hernandez et al.
      Pages 255-275
    6. Silvia Bassi, Takshashila Tripathi, Alan Monziani, Francesca Di Leva, Marta Biagioli
      Pages 277-299
  5. Elderly Disorders

    1. Front Matter
      Pages 301-301
    2. Rebecca G. Smith, Katie Lunnon
      Pages 303-319
    3. Pritika Narayan, Mike Dragunow
      Pages 321-336
    4. Rotem Maoz, Benjamin P. Garfinkel, Hermona Soreq
      Pages 337-361
    5. Maria Angeliki S. Pavlou, Tiago Fleming Outeiro
      Pages 363-390
  6. New Approaches for Neuroepigenomic Studies

    1. Front Matter
      Pages 391-391
    2. Amy Guillaumet-Adkins, Holger Heyn
      Pages 393-407
    3. Pavel Bashtrykov, Albert Jeltsch
      Pages 409-424
    4. Renzo J. M. Riemens, Edilene S. Soares, Manel Esteller, Raul Delgado-Morales
      Pages 443-475
    5. Vladimir Espinosa Angarica, Antonio del Sol
      Pages 489-512
  7. Back Matter
    Pages 513-525

About this book

Introduction

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease).

The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

Keywords

epigenomics genomics Neurodegenerative Diseases microRNAs modifications

Editors and affiliations

  • Raul Delgado-Morales
    • 1
  1. 1.Cancer Epigenetics and Biology Program (PEBC)Bellvitge Biomedical Research Institute (IDIBELL)CATALONIASpain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-53889-1
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-53888-4
  • Online ISBN 978-3-319-53889-1
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site