© 2017

Non-canonical Cyclic Nucleotides

  • Roland Seifert

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 238)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Sabine Wolter, Fanni Dittmar, Roland Seifert
    Pages 25-47
  3. Claudius Marondedze, Aloysius Wong, Ludivine Thomas, Helen Irving, Chris Gehring
    Pages 87-103
  4. Robin Lorenz, Daniela Bertinetti, Friedrich W. Herberg
    Pages 105-122
  5. Bryan VanSchouwen, Giuseppe Melacini
    Pages 123-133
  6. Jens Schlossmann, Stefanie Wolfertstetter
    Pages 149-167
  7. Erich H. Schneider, Roland Seifert
    Pages 169-205
  8. Susan W. S. Leung, Yuansheng Gao, Paul M. Vanhoutte
    Pages 209-228
  9. Arun K. Mankan, Martina Müller, Gregor Witte, Veit Hornung
    Pages 269-289
  10. Heike Bähre, Volkhard Kaever
    Pages 293-306
  11. Frank Schwede, Andreas Rentsch, Hans-Gottfried Genieser
    Pages 307-337
  12. Manuel Grundmann, Evi Kostenis
    Pages 339-357
  13. Frank Schwede, Hans-Gottfried Genieser, Andreas Rentsch
    Pages 359-384
  14. Back Matter
    Pages 385-387

About this book


The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.


bacterial toxins cyclic nucleotides mass spectrometry nucleotidyl cyclases protein kinases signal transduction

Editors and affiliations

  • Roland Seifert
    • 1
  1. 1.Medical School of Hannover Insitute of PharmakologyHannoverGermany

Bibliographic information