Proteomic Methods in Neuropsychiatric Research

  • Paul C. Guest

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 974)

Also part of the Proteomics, Metabolomics, Interactomics and Systems Biology book sub series (PMISB, volume 974)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Reviews

    1. Front Matter
      Pages 1-1
    2. Renã A. S. Robinson, Bushra Amin, Paul C. Guest
      Pages 21-48
    3. Paul C. Guest, Daniel Martins-de-Souza
      Pages 49-67
    4. Hassan Rahmoune, Daniel Martins-de-Souza, Paul C. Guest
      Pages 69-84
    5. Norma Galicia, Paula Díez, Rosa M. Dégano, Paul C. Guest, Nieves Ibarrola, Manuel Fuentes
      Pages 85-96
    6. Mariana Fioramonte, Paul C. Guest, Daniel Martins-de-Souza
      Pages 115-129
    7. Junfang Chen, Paul C. Guest, Emanuel Schwarz
      Pages 131-138
  3. Protocols

    1. Front Matter
      Pages 139-139
    2. Laurie Stephen, Emanuel Schwarz, Paul C. Guest
      Pages 149-156
    3. Veronica M. Saia-Cereda, Adriano Aquino, Paul C. Guest, Daniel Martins-de-Souza
      Pages 175-182
    4. Sheila Garcia, Licia C. Silva-Costa, Guilherme Reis-de-Oliveira, Paul C. Guest, Paulo A. Baldasso, Juliana S. Cassoli et al.
      Pages 193-203
    5. Guilherme Lanfredi, Guiherme Reis-de-Oliveira, Veronica M. Saia-Cereda, Paul C. Guest, Daniel Martins-de-Souza, Vitor M. Faça
      Pages 205-212
    6. Guilherme Reis-de-Oliveira, Sheila Garcia, Paul C. Guest, Juliana S. Cassoli, Daniel Martins-de-Souza
      Pages 213-218
    7. Erika Velásquez Núñez, Paul C. Guest, Daniel Martins-de-Souza, Gilberto Barbosa Domont, Fábio César Sousa Nogueira
      Pages 219-227
    8. Bradley J. Smith, Juliana S. Cassoli, Paul C. Guest, Daniel Martins-de-Souza
      Pages 229-236
    9. Caroline Brandão-Teles, Daniel Martins-de-Souza, Paul C. Guest, Juliana S. Cassoli
      Pages 269-277
    10. Giuliana S. Zuccoli, Daniel Martins-de-Souza, Paul C. Guest, Stevens K. Rehen, Juliana Minardi Nascimento
      Pages 279-287
    11. Daniella Duque-Guimarães, Thomas Prates Ong, Juliana de Almeida-Faria, Paul C. Guest, Susan E. Ozanne
      Pages 289-298
    12. Lan Wang, Hassan Rahmoune, Paul C. Guest
      Pages 305-311
    13. Divya Krishnamurthy, Hassan Rahmoune, Paul C. Guest
      Pages 313-319
    14. Harald Peter, Julia Wienke, Paul C. Guest, Nikitas Bistolas, Frank F. Bier
      Pages 339-349
  4. Future Perspectives

    1. Front Matter
      Pages 361-361

About this book


Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies. This book describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS) and selective reaction monitoring MS, to increase our understanding of these diseases, with the ultimate aim of improving patient care.

The volume will be of high interest to clinical scientists, physicians and pharmaceutical company scientists as it gives insights into the latest technologies enabling the revolution of personalized medicine.  It is of direct interest to both technical and bench biomarker scientists as it gives step by step instructions on how to carry out each of the protocols. It is also  of interest to researchers as each technique will be presented in the context of a specific neurological disorder, including Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder and bipolar disorder. 

Finally, it will also highlight the future research efforts in this field, which are endeavoring to convert proteomic platforms to the form of hand held devices which can be used in a point of care setting and return diagnostic results within the timeframe of a visit to the general practitioner.


mass spectrometry translational medicine two-dimensional gel electrophoresis immunoassay liquid chromatography pharmacology

Editors and affiliations

  • Paul C. Guest
    • 1
  1. 1.Department of Biochemistry and Tissue BiologyUniversity of Campinas (UNICAMP)CampinasBrazil

Bibliographic information