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© 2017

Candida albicans: Cellular and Molecular Biology

  • Rajendra Prasad
Book

Table of contents

  1. Front Matter
    Pages i-xii
    PDF
  2. Introduction
    Rajendra Prasad
    Pages 1-4
  3. Current Trends in Candidiasis
    Priya Uppuluri, Afshin Khan, John E. Edwards
    Pages 5-23
  4. Invasive Candidiasis in the Southeast-Asian Region
    Rachna Singh, Arunaloke Chakrabarti
    Pages 25-40
  5. Morphogenesis in C. albicans
    David Kadosh
    Pages 41-62
  6. Candida albicans Biofilms
    Priya Uppuluri, Jose Luis Lopez Ribot
    Pages 63-75
  7. Candida Biofilm Tolerance: Comparison of Planktonic and Biofilm Resistance Mechanisms
    Eddie G. Dominguez, David R. Andes
    Pages 77-92
  8. In Vivo Candida Device Biofilm Models
    David R. Andes
    Pages 93-113
  9. Fungal–Bacterial Interactions: In Health and Disease
    Patrick Van Dijck, Mary Ann Jabra-Rizk
    Pages 115-143
  10. Host Immune Responses During Infections with Candida albicans
    Mark H. T. Stappers, Gordon D. Brown
    Pages 145-183
  11. AMPlified Defense: Antimicrobial Peptides During Candida albicans Infection
    Joachim F. Ernst, Marc Swidergall
    Pages 185-203
  12. Genome Diversity and Dynamics in Candida albicans
    Christophe d’Enfert, Marie-Elisabeth Bougnoux, Adeline Feri, Mélanie Legrand, Raphaël Loll-Krippleber, Timea Marton et al.
    Pages 205-232
  13. Chromosome Components Important for Genome Stability in Candida albicans and Related Species
    Lakshmi Sreekumar, Neha Varshney, Kaustuv Sanyal
    Pages 233-251
  14. Infection-Associated Gene Expression—The Pathogen Perspective
    Saranna Fanning, Aaron P. Mitchell
    Pages 253-269
  15. Signaling Mechanisms in Pathogenesis and Virulence of Candida albicans
    Neeraj Chauhan
    Pages 271-286
  16. Mechanisms of Drug Resistance in Candida albicans
    Dominique Sanglard
    Pages 287-311
  17. Unlocking the Therapeutic Potential of the Fungal Cell Wall: Clinical Implications and Drug Resistance
    Chibuike Ibe, Louise A. Walker, Neil A. R. Gow, Carol A. Munro
    Pages 313-346
  18. Iron Acquisition in the Pathobiology of Candida albicans
    Manjit Kumar Srivastav, Remya Nair, Krishnamurthy Natarajan
    Pages 347-378
  19. Structure–Function Analyses of Multidrug Transporters
    Erwin Lamping, Golnoush Madani, Hee Ji Lee, Masakazu Niimi, Richard D. Cannon
    Pages 379-406
  20. MDR1 and Its Regulation
    Joachim Morschhäuser
    Pages 407-415
  21. Insights into Candida Lipids
    Rajendra Prasad, Sudhanshu Shukla, Ashutosh Singh
    Pages 417-428
  22. Molecular Targets for Anticandidal Chemotherapy
    Sławomir Milewski
    Pages 429-469
  23. Antifungals
    David S. Perlin
    Pages 471-489
  24. Using Yeast to Discover Inhibitors of Multidrug Efflux in Candida albicans
    Brian C. Monk, Mikhail V. Keniya
    Pages 491-543
  25. Inhibitors of Cancer Cell Multidrug ABC Transporters: Extrapolation to Combat Candida albicans Resistance to Antifungals
    Attilio Di Pietro
    Pages 545-554

About this book

Introduction

This book on Candida albicans and similar pathogens provides a timely overview of the groundbreaking discoveries made in the areas of drug resistance, host–pathogen interactions, virulence, host immune system modulation, etc., in the last two decades.

 This comprehensive 2nd Edition includes chapters on fungal infections, hyphal morphogenesis, molecular mechanisms of antifungal resistance, antifungal agents, multidrug transporters, virulence mechanisms in Candida albicans, host–pathogen interactions, the cell wall, fungal biofilms, lipids and antifungal resistance, signaling mechanisms and last but not the least host-immune responses. As such, it offers an ideal reference guide for mycologists, researchers, pharmacists, clinicians, and undergraduate students engaged or interested in fungal research. It will also benefit clinicians, who are required to keep abreast of the current state of research on antifungal drug resistance and antifungal development.

Keywords

Fungal Infections Candida Species Biofilm Development Drug Resistance Multi-drug Transporter Fungal Resistance

Editors and affiliations

  • Rajendra Prasad
    • 1
  1. 1.Amity Institute of Integrative Sciences and Health and Amity Institute of BiotechnologyAmity Institute of Integrative Sciences and Health and Amity Institute of Biotechnology, Amity University HaryanaGurgaonIndia

About the editors

Prof. Rajendra Prasad has recently joined Amity University, Gurgaon as Director of the Amity Institute of Biotechnology and Amity Integrative Sciences and Health. He is a former Professor & Dean of the School of Life Sciences at Jawaharlal Nehru University (JNU), New Delhi, where he served for 40 years in various capacities which included Chairman of Molecular Medicine and Rector (Pro-Vice-Chancellor). Holding a Ph.D. from the Central Drug Research Institute, Lucknow, Prof. Prasad has also served as a visiting professor at several universities and institutes, including the Ecole Normale Superieure – CNRS Paris, France; Catholic University, Louvain-la – Neuve, Belgium; Technical University, Valencia, Spain; Bristol Mayer Squib, Princeton, USA; University of Darmstadt, Germany; and New York Medical College, USA. 

Prof. Prasad is a recipient of the Royal Society Commonwealth Bursary, Alexander von Humboldt-Stiftung Fellowship, Welcome Foundation Grant, and the Mercator Professorship at the University of Bonn. He is an elected fellow of all Indian Science Academies, a European Commission Focal Point Coordinator, and a Research Ambassador, Germany. He is also currently Vice President of the Indian National Science Academy, New Delhi.

Prof. Prasad has published over 225 research papers and has handled 50 national and international grants. He is a leading molecular mycologist and has conducted trendsetting research in the area of antifungal clinical drug resistance.

Bibliographic information