Imaging and Focal Therapy of Early Prostate Cancer

  • Thomas J. Polascik

Part of the Current Clinical Urology book series (CCU)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Why Focal Therapy?

    1. Front Matter
      Pages 1-1
    2. Isabel García-Fleury, Chi-hang Yee, Marco Antonio López-Tovar, Adriana Pesci-Feltri, Arjun Sivaraman, Rafael Sanchez-Salas
      Pages 3-19
    3. Zhamshid Okhunov, Roshan M. Patel, Jaime Landman
      Pages 21-38
    4. Kae Jack Tay, Thomas J. Polascik
      Pages 39-48
  3. Global Perspective of Active Surveillance and Focal Therapy

    1. Front Matter
      Pages 49-49
    2. Jan Philipp Radtke, Angelo Territo, Markus Hohenfellner, Alberto Breda
      Pages 57-74
    3. Masaki Kimura, Kae Jack Tay, Satoru Muto, Shigeo Horie
      Pages 75-81
  4. Scientific Foundation for the Focal Therapy Concept

    1. Front Matter
      Pages 83-83
    2. Vladimir Mouraviev, Arnauld Villers, Thomas M. Wheeler, Rodolfo Montironi, Pierre Nevoux, Ariel Schulman et al.
      Pages 85-104
    3. Lina Maria Carmona Echeverria, Hayley Whitaker, Hashim U. Ahmed
      Pages 105-113
    4. Robert Qi, Stephen J. Freedland, Judd W. Moul
      Pages 115-128
    5. Arjun Sivaraman, Rafael Sanchez-Salas
      Pages 129-137
  5. Multiparametric MRI and ARFI Imaging of the Prostate

    1. Front Matter
      Pages 145-145
    2. Sonia Gaur, Sherif Mehralivand, Baris Turkbey, Peter L. Choyke
      Pages 161-176
    3. Mark L. Palmeri, Kathryn R. Nightingale
      Pages 193-202
  6. Prostate Biopsy Techniques

    1. Front Matter
      Pages 203-203
    2. Igor Trilisky, Aytekin Oto, Scott Eggener
      Pages 205-218
    3. Akhil Muthigi, Ardeshir R. Rastinehad, Arvin K. George, Masakatsu Oishi, Osamu Ukimura, Peter A. Pinto
      Pages 219-237
    4. Arnoud W. Postema, Jochen Walz, Hessel Wijkstra
      Pages 251-263
    5. Wesley W. Ludwig, Mohamad E. Allaf, Dan Stoianovici
      Pages 265-273
  7. Technologies for Focal Therapy: Transperineal Approach

    1. Front Matter
      Pages 275-275
    2. Nathan Perlis, John Trachtenberg, Sangeet Ghai
      Pages 277-282
    3. Kae Jack Tay, Efrat Tsivian, Thomas J. Polascik
      Pages 283-291
    4. Caroline M. Moore, Mark Emberton
      Pages 293-306
  8. Technologies for Focal Therapy: Transrectal Approach

    1. Front Matter
      Pages 307-307
    2. Paolo Capogrosso, Eric Barret
      Pages 309-323
    3. John F. Feller, Bernadette M. Greenwood, R. Jason Stafford
      Pages 325-343
  9. New Approaches and Applications of Focal Therapy

    1. Front Matter
      Pages 345-345
    2. Vikram Narayan, Badrinath R. Konety, Thomas S. Griffith
      Pages 347-354
    3. Arnauld Villers, Kae Jack Tay
      Pages 373-382
  10. Manipulating the Microenvironment for Optimization

    1. Front Matter
      Pages 383-383
    2. Kimberly L. Santucci, John M. Baust, Kristi K. Snyder, Anthony Robilotto, Robert G. VanBuskirk, John G. Baust
      Pages 385-397
    3. Nathan Perlis, Antonio Finelli
      Pages 399-405
  11. Determining Outcomes of Focal Therapy

    1. Front Matter
      Pages 407-407
    2. Rafael E. Jimenez, Andrew Evans, James Kench, Rodolfo Montironi, Mahul B. Amin
      Pages 417-429
    3. Theo M. de Reijke, Arnoud W. Postema, J. Stephen Jones
      Pages 443-446
    4. Matthijs J. V. Scheltema, Anouk E. Hentschel, Jean J. M. C. H. de la Rosette
      Pages 447-463
  12. Back Matter
    Pages 465-483

About this book


This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality.  Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation.  

Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients. 

Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians –- residents, fellows, nurses and allied professionals -- and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.


active surveillance index lesion prostate ablation MRI targeted biopsy Cell Electroporation Photodynamic Therapy

Editors and affiliations

  • Thomas J. Polascik
    • 1
  1. 1.Department of SurgeryDuke Cancer InstituteDurhamUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-49910-9
  • Online ISBN 978-3-319-49911-6
  • Series Print ISSN 2197-7194
  • Series Online ISSN 2197-7208
  • Buy this book on publisher's site