Malignant Brain Tumors

State-of-the-Art Treatment

  • Jennifer Moliterno Gunel
  • Joseph M Piepmeier
  • Joachim M. Baehring

Table of contents

  1. Front Matter
    Pages i-xi
  2. Molecular and Clinical Characterization of Gliomas

    1. Front Matter
      Pages 1-1
    2. Mark W. Youngblood, E. Zeynep Erson-Omay, Murat Günel
      Pages 31-48
  3. Surgery: Maximizing the Extent of Tumor Resection

    1. Front Matter
      Pages 49-49
    2. Gregory Kuzmik, Anne Long, S. Bulent Omay, Jennifer Moliterno Günel
      Pages 51-62
    3. Emmanuel Mandonnet, Hugues Duffau
      Pages 63-79
    4. Elena Fomchenko, Veronica L. S. Chiang
      Pages 103-119
  4. Adjuvant Therapies

    1. Front Matter
      Pages 121-121
    2. Kevin P. Becker, Joachim M. Baehring
      Pages 123-131
    3. Jacob Mandel, Santosh Kesari
      Pages 133-150
    4. Owen Clark, Christian Grommes
      Pages 151-161
    5. Nancy Wang, Jonas Kloepper, Rakesh K. Jain, Tracy T. Batchelor
      Pages 163-175
    6. Teilo H. Schaller, John H. Sampson
      Pages 177-192
    7. David S. Hersh, Aniket S. Wadajkar, Graeme F. Woodworth
      Pages 193-216
    8. Laura E. G. Warren, Marc R. Bussiére, Helen A. Shih
      Pages 217-231
    9. Christopher D. Corso, Ranjit S. Bindra
      Pages 233-240
  5. Tumor-Specific Approach

    1. Front Matter
      Pages 241-241
    2. Ghazaleh Tabatabai
      Pages 243-249
    3. Charles Marc Leyrer, Erin Murphy, Manmeet Ahluwalia
      Pages 251-263
    4. Hans-Georg Wirsching, Michael Weller
      Pages 265-288
  6. Back Matter
    Pages 289-297

About this book


This text addresses all aspects of patient evaluation and care. This includes new findings in imaging that provide a better understanding of the extent of the lesion as well as its relationship with critical neuroanatomic function. The evolution of intraoperative imaging, functional brain mapping,and technology to identify tumor from brain is covered. This has significantly improved the ability of surgeons to more safely and aggressively remove tumors.More importantly, a better understanding of tumor biology and genomics has created an opportunity to significantly revise tumor classification and better select optimal therapy for individual patients. The text covers novel and innovative treatment options including immunotherapy, tumor vaccines, antiangiogenic agents,and personalized cancer treatment.  In addition, novel agent delivery techniques are covered to offer the potential for increasing the effectiveness of treatment by delivering active agents directly where they are needed most.

Malignant Brain Tumors: State-of-the-Art Treatment provides a comprehensive overview of treatment for malignant gliomas, and will prove useful by updating physicians on new therapeutic paradigms and what is on the horizon for the near future. This text will be informative for surgeons, oncologists, neurologists, residents and students who treat these patients,as well as those who are training for a career in managing patients with these challenging tumors.


Biology of Gliomas Neuro-Imaging Intraoperative Imaging Fluorescence-guided resection Antiangiogenic Therapy Oligodendroglioma Glioblastoma multiforme

Editors and affiliations

  • Jennifer Moliterno Gunel
    • 1
  • Joseph M Piepmeier
    • 2
  • Joachim M. Baehring
    • 3
  1. 1.Neurosurgical OncologyYale University School of Medicine Neurosurgical OncologyNew HavenUSA
  2. 2.Yale University School of MedicineNew HavenUSA
  3. 3.Yale School of MedicineNew HavenUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-49863-8
  • Online ISBN 978-3-319-49864-5
  • Buy this book on publisher's site