Cellular Therapies for Retinal Disease

A Strategic Approach

  • Steven D. Schwartz
  • Aaron Nagiel
  • Robert Lanza

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Cell Replacement Therapy

    1. Front Matter
      Pages 1-1
    2. Ninel Z. Gregori, Carlos A. Medina, Mira M. Sachdeva, Dean Eliott
      Pages 3-17
    3. Odysseas Georgiadis, Lyndon da Cruz, Peter Coffey
      Pages 19-31
    4. Vladimir Khristov, Balendu Shekhar Jha, Aaron Rising, Yichao Li, Haohua Qian, Arvydas Maminishkis et al.
      Pages 33-44
    5. Meena S. George, Hossein Nazari, Debbie Mitra, Dennis Clegg, David R. Hinton, Mark S. Humayun
      Pages 45-54
    6. Priya Sharma, Jayanth Sridhar, Carl D. Regillo
      Pages 55-64
    7. Xiong Zhang, Praseeda Venugopalan, Jeffrey L. Goldberg
      Pages 65-76
  3. Cell-based Neuroprotection

    1. Front Matter
      Pages 77-77
    2. Elad Moisseiev, Susanna S. Park
      Pages 79-94
    3. James S. Baldassarre, Anthony Joseph, Michael Keane, Jeffrey S. Heier
      Pages 95-104
  4. Disease Modeling Using Induced Pluripotent Stem Cells

    1. Front Matter
      Pages 105-105
    2. Huy V. Nguyen, Stephen H. Tsang
      Pages 107-115
    3. Jennifer G. Aparicio, Dominic W. H. Shayler, David Cobrinik
      Pages 117-138
  5. Back Matter
    Pages 139-143

About this book

Introduction

This book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book—edited by world-renowned stem cell scientists—focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation.

The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.

Keywords

Cell-based Neuroprotection Cell Transplantation Choriocapillaris Pluripotent Stem Cells Retinal Pigment

Editors and affiliations

  • Steven D. Schwartz
    • 1
  • Aaron Nagiel
    • 2
  • Robert Lanza
    • 3
  1. 1.Retina Division Chief; Department of Ophthalmology; Ahmanson Professor of OphthalmologyStein Eye Institute; David Geffen School of Medicine at UCLALos AngelesUSA
  2. 2.Retina Division; Department of OphthalmologyStein Eye Institute; David Geffen School of Medicine at UCLALos AngelesUSA
  3. 3.Head of Astellas Global Regenerative MedicineChief Scientific Officer at the Astellas Institute for Regenerative MedicineMarlboroughUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-49479-1
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-49477-7
  • Online ISBN 978-3-319-49479-1
  • About this book