Oxidative Stress in Human Reproduction

Shedding Light on a Complicated Phenomenon

  • Ashok Agarwal
  • Rakesh Sharma
  • Sajal Gupta
  • Avi Harlev
  • Gulfam Ahmad
  • Stefan S. du Plessis
  • Sandro C. Esteves
  • Siew May Wang
  • Damayanthi Durairajanayagam

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Gulfam Ahmad, Mazen Almasry, Amolak S. Dhillon, Muna M. Abuayyash, Narasimhan Kothandaraman, Zeynep Cakar
    Pages 1-16
  3. Rakesh Sharma, Shubhadeep Roychoudhury, Nirvika Singh, Yash Sarda
    Pages 17-46
  4. Stefan S. du Plessis, Avi Harlev, Mohamed Iesar Mohamed, Eiad Habib, Narasimhan Kothandaraman, Zeynep Cakar
    Pages 47-64
  5. Rakesh Sharma, Shubhadeep Roychoudhury, Rakan Alsaad, Fares Bamajbuor
    Pages 65-87
  6. Avi Harlev, Stefan S. du Plessis, Deepak Kumar, Luay AlKattan
    Pages 89-105
  7. Sajal Gupta, Gulfam Ahmad, My Tran, Ghada Al Hayaza, Zeina Kayali
    Pages 107-127
  8. Sajal Gupta, Stefan S. du Plessis, Saad AlQasem, Mohammad Nouh, Zeynep Cakar
    Pages 129-150
  9. Damayanthi Durairajanayagam, Amolak S. Dhillon, Rian Salasin, Anthony Kashou, Narasimhan Kothandaraman
    Pages 151-190

About this book


This book discusses the role of oxidative stress in the reproductive system. The book reviews endogenous sources, methods of determining its levels in body fluid/tissues, the physiological roles of ROS, as well as its negative effects on the human reproductive processes. Also discussed are multiple extrinsic factors that could induce oxidative stress in the reproductive system. This brief covers various clinical pathologies related to the reproductive system that arise from or produce oxidative stress, both in the male and female. The use of antioxidants as a therapeutic measure to keep ROS levels in check are highlighted, describing the outcome of various clinical studies involving antioxidant supplementation in infertile patients. Infertility is a global disease that affects 15-25% of all couples, and oxidative stress arising from a multitude of sources has been implicated as one of the major contributing factors to the decline in human fertility. As such, this book provides an up-to-date review on the significance of ROS in human reproduction.


antioxidant therapy fertility human reproduction infertility oxidative stress reactive oxygen species

Editors and affiliations

  • Ashok Agarwal
    • 1
  • Rakesh Sharma
    • 2
  • Sajal Gupta
    • 3
  • Avi Harlev
    • 4
  • Gulfam Ahmad
    • 5
  • Stefan S. du Plessis
    • 6
  • Sandro C. Esteves
    • 7
  • Siew May Wang
    • 8
  • Damayanthi Durairajanayagam
    • 9
  1. 1.American Center for Reproductive MedicineCleveland ClinicClevelandUSA
  2. 2.American Center for Reproductive MedicineCleveland ClinicClevelandUSA
  3. 3.American Center for Reproductive MedicineCleveland ClinicClevelandUSA
  4. 4.Department of Obstetrics & Gynecology, F-IVFSoroka University Medical Center Ben-Gurion University of the NegevSansanaIsrael
  5. 5.College of MedicinePrince Sattam Bin Abdulaziz UniversityAl Kharj, KSASaudi Arabia
  6. 6.Division of Medical PhysiologyStellenbosch UniversityTygerbergSouth Africa
  7. 7.Androfert Referral Center for Male ReproductionCampinasBrazil
  8. 8.American Center for Reproductive MedicineCleveland ClinicClevelandUSA
  9. 9.Faculty of MedicineUniversiti Teknologi MARASungai BulohMalaysia

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-48425-9
  • Online ISBN 978-3-319-48427-3
  • Buy this book on publisher's site