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Obesity and Lipotoxicity

  • Book
  • © 2017

Overview

Editors:
  1. Ayse Basak Engin

    1. Faculty of Pharmacy, Department of Toxicology, Gazi University, Hipodrom, Turkey

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    You can also search for this editor in PubMed   Google Scholar

  2. Atilla Engin

    1. Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Turkey

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • A comprehensive overview of obesity and lipotoxicity
  • Discusses the mechanisms of obesity and possibilities for the development of new treatment strategies
  • Overview of the biochemical pathways leading to obesity-related metabolic disorders
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 960)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. The Definition and Prevalence of Obesity and Metabolic Syndrome

    • Atilla Engin
    Pages 1-17

  3. Circadian Rhythms in Diet-Induced Obesity

    • Atilla Engin
    Pages 19-52

  4. Eat and Death: Chronic Over-Eating

    • Atilla Engin
    Pages 53-80

  5. Obesity, Persistent Organic Pollutants and Related Health Problems

    • Loukia Vassilopoulou, Christos Psycharakis, Demetrios Petrakis, John Tsiaoussis, Aristides M. Tsatsakis
    Pages 81-110

  6. Human Protein Kinases and Obesity

    • Atilla Engin
    Pages 111-134

  7. Fat Cell and Fatty Acid Turnover in Obesity

    • Atilla Engin
    Pages 135-160

  8. Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome

    • Stefania Carobbio, Vanessa Pellegrinelli, Antonio Vidal-Puig
    Pages 161-196

  9. What Is Lipotoxicity?

    • Ayse Basak Engin
    Pages 197-220

  10. The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation

    • Atilla Engin
    Pages 221-245

  11. Microbiota and Lipotoxicity

    • Evren Doruk Engin
    Pages 247-260

  12. Endoplasmic Reticulum Stress and Obesity

    • Erkan Yilmaz
    Pages 261-276

  13. Insulin Resistance, Obesity and Lipotoxicity

    • Dilek Yazıcı, Havva Sezer
    Pages 277-304

  14. Adipose Tissue Hypoxia in Obesity and Its Impact on Preadipocytes and Macrophages: Hypoxia Hypothesis

    • Atilla Engin
    Pages 305-326

  15. Adipocyte-Macrophage Cross-Talk in Obesity

    • Ayse Basak Engin
    Pages 327-343

  16. Endothelial Dysfunction in Obesity

    • Atilla Engin
    Pages 345-379

  17. Diet-Induced Obesity and the Mechanism of Leptin Resistance

    • Atilla Engin
    Pages 381-397

  18. Influence of Antioxidants on Leptin Metabolism and its Role in the Pathogenesis of Obesity

    • Harald Mangge, Christian Ciardi, Kathrin Becker, Barbara Strasser, Dietmar Fuchs, Johanna M. Gostner
    Pages 399-413

  19. Adiponectin-Resistance in Obesity

    • Atilla Engin
    Pages 415-441

  20. Non-Alcoholic Fatty Liver Disease

    • Atilla Engin
    Pages 443-467
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Keywords

About this book

Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.

Reviews

“The aim is to discuss the many critical and complex topics that trigger obesity with the hope that the book will encourage and further the research of scientists and practitioners who are interested in obesity. … This book is intended as a useful resource for clinicians and basic science researchers such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, and cardiologists, as well as students who are interested in this field.” (L. Anne Gilmore, Doody's Book Reviews, September, 2017)

Editors and Affiliations

  • Faculty of Pharmacy, Department of Toxicology, Gazi University, Hipodrom, Turkey

    Ayse Basak Engin

  • Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Turkey

    Atilla Engin

Bibliographic Information

  • Book Title: Obesity and Lipotoxicity

  • Editors: Ayse Basak Engin, Atilla Engin

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-48382-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017

  • Hardcover ISBN: 978-3-319-48380-1Published: 12 June 2017

  • Softcover ISBN: 978-3-319-83928-8Published: 12 June 2018

  • eBook ISBN: 978-3-319-48382-5Published: 05 June 2017

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 624

  • Number of Illustrations: 12 b/w illustrations, 35 illustrations in colour

  • Topics: Biochemistry, general, Pharmacology/Toxicology, Endocrinology

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