© 2017

The CAPRISA Clinical Trials: HIV Treatment and Prevention

  • Quarraisha Abdool Karim
  • Salim S. Abdool Karim
  • Cheryl Baxter

Table of contents

  1. Front Matter
    Pages i-vi
  2. Introduction/Background

    1. Front Matter
      Pages 1-1
    2. Quarraisha Abdool Karim, Cheryl Baxter, Salim S. Abdool Karim
      Pages 3-13
    3. Salim S. Abdool Karim, Cheryl Baxter, Quarraisha Abdool Karim
      Pages 15-25
    4. Anneke Grobler
      Pages 27-38
  3. CAPRISA Clinical Trials for HIV and HSV-2 Prevention

    1. Front Matter
      Pages 39-39
    2. Cheryl Baxter, Leila E. Mansoor, Tanuja N. Gengiah, Salim S. Abdool Karim, Quarraisha Abdool Karim
      Pages 41-56
    3. Leila E. Mansoor, Kathryn T. Mngadi, Quarraisha Abdool Karim
      Pages 57-75
    4. Hilton Humphries, Ayesha B. M. Kharsany, Kerry Leask, Fanelesibonge Ntombela, Quarraisha Abdool Karim
      Pages 77-89
    5. Nigel Garrett, Kathryn Mngadi, Nivashnee Naicker, Lynn Morris
      Pages 91-104
  4. CAPRISA Clinical Trials for HIV–TB Treatment

    1. Front Matter
      Pages 105-105
    2. Nesri Padayatchi, Kogie Naidoo, Andy Gray, Salim S. Abdool Karim, Anneke Grobler
      Pages 107-120
    3. Kogieleum Naidoo, Santhanalakshmi Gengiah, Nesri Padayatchi, Salim S. Abdool Karim
      Pages 121-134
  5. Experiences and Lessons Learnt from Clinical Trials in CAPRISA

    1. Front Matter
      Pages 135-135
    2. Carolyn Williamson, Lynn Morris, Nigel Garrett, Penny Moore, Wendy Burgers, Koleka Mlisana
      Pages 137-152
    3. Jo-Ann S. Passmore, Lenine L. Liebenberg, Nonhlanhla N. Mkhize, Derseree Archary, Lindi Masson
      Pages 153-166
  6. Essential Support Activities for the Conduct of Clinical Trials

    1. Front Matter
      Pages 167-167
    2. Tanuja N. Gengiah, Natasha Samsunder, Janet A. Frohlich, Fanelesibonge Ntombela
      Pages 169-189
    3. Marian Swart, Devenie Latchmanan, Nasrin Amla, Carl Montague
      Pages 201-207

About this book


Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA’s high impact studies was created, developed, implemented, analysed and communicated.  In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics.

Comprised of 5 sections, the book details the following:

  1. HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV.
  2. CAPRISA’s clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies.
  3. CAPRISA’s research on the treatment of HIV and TB co-infection.
  4. A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology. 
  5. Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials.

The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials – their creation, conduct and impact.


AIDS HIV Clinical Trials Prevention Treatment Tuberculosis

Editors and affiliations

  • Quarraisha Abdool Karim
    • 1
  • Salim S. Abdool Karim
    • 2
  • Cheryl Baxter
    • 3
  1. 1.CAPRISAUniversity of KwaZulu-NatalDurbanSouth Africa
  2. 2.CAPRISAUniversity of KwaZulu-NatalDurbanSouth Africa
  3. 3.CAPRISAUniversity of KwaZulu-NatalDurbanSouth Africa

About the editors

Quarraisha Abdool Karim, Centre for the AIDS Programme of Research in South Africa (CAPRISA); Department of Epidemiology, Columbia University, New York, USA

Salim S. Abdool Karim, Centre for the AIDS Programme of Research in South Africa (CAPRISA); Department of Epidemiology, Columbia University, New York, USA

Cheryl Baxter, Centre for the AIDS Programme of Research in South Africa (CAPRISA)

Bibliographic information