Antimicrobial Drug Resistance

Mechanisms of Drug Resistance, Volume 1

  • Douglas L. Mayers
  • Jack D. Sobel
  • Marc Ouellette
  • Keith S. Kaye
  • Dror Marchaim

Table of contents

  1. Front Matter
    Pages i-xxi
  2. General Overview

    1. Front Matter
      Pages 1-1
    2. George A. Jacoby
      Pages 3-8
    3. Fernando Baquero, Rafael Cantón
      Pages 9-36
    4. Elizabeth R. Andrews, Angela D. M. Kashuba
      Pages 37-43
    5. Jacques Dumas, Michael J. Pucci, Greg Moeck
      Pages 45-57
  3. General Mechanisms of Drug Resistance

    1. Front Matter
      Pages 59-59
    2. Paul H. Roy, Sally R. Partridge
      Pages 61-76
    3. Liza Valdivia, Louis B. Rice
      Pages 89-95
    4. Vanessa M. D’Costa, Gerard D. Wright
      Pages 97-113
    5. Lucía Fernández, Joseph B. McPhee, Sandeep Tamber, Michelle D. Brazas, Shawn Lewenza, Robert E. W. Hancock
      Pages 115-130
    6. Elias K. Manavathu, Jose A. Vazquez
      Pages 149-162
  4. Bacterial Drug Resistance: Mechanisms

    1. Front Matter
      Pages 163-163
    2. André Zapun, Pauline Macheboeuf, Thierry Vernet
      Pages 177-211
    3. Alisa W. Serio, Maria L. Magalhães, John S. Blanchard, Lynn E. Connolly
      Pages 213-229
    4. Marilyn C. Roberts, Stefan Schwarz
      Pages 231-243
    5. Bryan D. Schindler, Joseph Adrian L. Buensalido, Glenn W. Kaatz
      Pages 245-263
    6. George A. Jacoby
      Pages 265-268
    7. Vincent Cattoir, Roland Leclercq
      Pages 269-280
    8. Shira I. Doron, Kirthana R. Beaulac, Abhay Dhand, David R. Snydman
      Pages 281-287
    9. Florence Depardieu, Patrice M. Courvalin
      Pages 289-305
    10. Jordan R. Smith, Kimberly C. Claeys, Evan J. Zasowski, Juwon Yim, Michael J. Rybak
      Pages 307-317
    11. Eleni Ntokou, Birte Vester
      Pages 319-332
    12. Matthew D. Johnson, Roger L. Nation, Jian Li
      Pages 333-344
    13. Ola E. Sköld, Göte Swedberg
      Pages 345-358
    14. Noton K. Dutta, Petros C. Karakousis
      Pages 359-383
  5. Fungal Drug Resistance: Mechanisms

    1. Front Matter
      Pages 385-385
    2. Matthew McCarthy, Elizabeth M. O’Shaughnessy, Thomas J. Walsh
      Pages 387-395
    3. Jose L. Lopez-Ribot, Nathan P. Wiederhold, Thomas F. Patterson
      Pages 397-405
    4. Jyotsna Chandra, Mahmoud A. Ghannoum
      Pages 407-413
    5. David S. Perlin
      Pages 415-428
  6. Viral Drug Resistance: Mechanisms

    1. Front Matter
      Pages 477-477
    2. Brian D. Herman, Robert A. Domaoal, Maryam Ehteshami, Raymond F. Schinazi
      Pages 503-519
    3. Colin M. Venner, Annette N. Ratcliff, Mathieu Coutu, Andrés Finzi, Eric J. Arts
      Pages 545-557
    4. Ying-Shan Han, Thibault Mesplède, Mark A. Wainberg
      Pages 559-564
    5. Bianca Heinrich, John P. Bilello
      Pages 579-609
  7. Parasitic Drug Resistance: Mechanisms

    1. Front Matter
      Pages 611-611
    2. Consuelo Gómez García, Laurence A. Marchat, Lilia López-Cánovas, D. Guillermo Pérez Ishiwara, Mario A. Rodríguez, Esther Orozco
      Pages 613-628
    3. Giancarlo A. Biagini, Stephen A. Ward
      Pages 629-647
    4. Goutam Mandal, Vaidya Govindarajan, Mansi Sharma, Hiranmoy Bhattacharjee, Rita Mukhopadhyay
      Pages 649-665
    5. Fabrice E. Graf, Pascal Mäser
      Pages 667-676

About this book


The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.


antibiotics antivirals drug resistance infectious disease bacteria pathogen antifungal

Editors and affiliations

  • Douglas L. Mayers
    • 1
  • Jack D. Sobel
    • 2
  • Marc Ouellette
    • 3
  • Keith S. Kaye
    • 4
  • Dror Marchaim
    • 5
  1. 1.Treiber TherapeuticsCambridgeUSA
  2. 2.Wayne State University School of Medicine, Detroit Medical CenterDetroitUSA
  3. 3.Centre de recherche en InfectiologieUniversity of LavalQuebec CityCanada
  4. 4.Division of Infectious DiseasesUniversity of Michigan Medical SchoolAnn ArborUSA
  5. 5.Infection Control and Prevention Unit of Infectious Diseases, Assaf Harofeh Medical Center, Sackler Faculty of MedicineTel-Aviv UniversityTel AvivIsrael

Bibliographic information