© 2017

Reducing Mortality in the Perioperative Period

  • Giovanni Landoni
  • Laura Ruggeri
  • Alberto Zangrillo

Table of contents

  1. Front Matter
    Pages i-vi
  2. Massimiliano Greco, Pier Carlo Bergonzi, Luca Cabrini
    Pages 9-14
  3. Paolo Feltracco, Daniela Pasero, Laura Ruggeri
    Pages 15-22
  4. Caetano Nigro Neto, Alexandre Slullitel, John G. Augoustides
    Pages 29-34
  5. Massimiliano Greco, Gianluca Paternoster, Daniela Mamo
    Pages 47-54
  6. Hesham R. Omar, Devanand Mangar, Enrico M. Camporesi
    Pages 55-62
  7. Antonella Capasso, Federico Masserini, Antonio Pisano
    Pages 63-71
  8. Emily MacKay, Aris Sophocles, George Silvay, John G. T. Augoustides
    Pages 73-77
  9. Luciano Silvestri, Hendrick K. F. van Saene
    Pages 79-86
  10. Łukasz J. Krzych, Maciej T. Wybraniec
    Pages 87-95
  11. Andrea Székely, Daniel Lex, Béla Merkely
    Pages 97-103
  12. Evgeny Fominskiy, Carmine D. Votta, Vladimir V. Lomivorotov
    Pages 105-111
  13. Hynek Riha, Tomas Drabek
    Pages 121-129
  14. Giovanni Borghi, Roberta Maj, Laura Ruggeri
    Pages 131-136
  15. Marta Mucchetti, Giovanni Landoni
    Pages 137-146

About this book


This second edition presents the first update on a consensus process during which all evidence from the literature with a survival benefit in the perioperative period was gathered, and in which 500 physicians from 61 countries worked to confirm the findings.

Perioperative morbidity and mortality currently represent a public health problem, as mortality alone is 1-4% in Western countries. Surprisingly, randomized evidence of survival benefit in the perioperative period is available for only 12 topics, while two drugs have been demonstrated to increase mortality. This book offers a complete description of each topic with updated evidence from the literature. Each chapter deals with a specific drug or technique and is structured into the following: background knowledge, main evidence from the literature, and a practical how-to section. Lastly, the book describes in detail the consensus process used, which served to reinforce the systematic review and which is currently being used and improved in other settings with growing success.

Written by respected international experts, Reducing Mortality in the Perioperative Period, 2nd ed. will be of interest to a wide variety of specialists, including anesthesiologists, intensivists, surgeons and cardiologists.


Anesthesia Surgery Survival Randomized Consensus

Editors and affiliations

  • Giovanni Landoni
    • 1
  • Laura Ruggeri
    • 2
  • Alberto Zangrillo
    • 3
  1. 1.Anestesia Rianimazione e Terapia IntensivaUniversità Vita-Salute San Raffaele Ospedale San RaffaeleMilanItaly
  2. 2.Anestesia Rianimazione e Terapia IntensivaUniversità Vita-Salute San Raffaele Ospedale San RaffaeleMilanItaly
  3. 3.Anestesia Rianimazione e Terapia IntensivaUniversità Vita-Salute San Raffaele Ospedale San RaffaeleMilanItaly

About the editors

Giovanni Landoni is currently an Associate Professor at Vita-Salute San Raffaele University, Milan, where he works as Head of Research in the Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute. Dr. Landoni is the Italian member of the Representative Council of the European Association of Cardiothoracic Anesthesiologists (EACTA, 2012–17). He is a past Vice-President of the Italian Association of Cardiothoracic Anesthesiologists (ITACTA) and a member of the ECMO team at San Raffaele Scientific Institute. He serves on the editorial boards of several international journals and his strong clinical and research interests in intensive care and anesthesia have resulted in more than 400 scientific publications, including more than 250 in indexed journals (he has an H index of 31).

Laura Ruggeri is a Resident at the Dept. of Anesthesia and Intensive Care,San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan (Italy). Dr. Ruggeri has authored several publications, serves on the editorial board of Heart, Lung and Vessels and as a guest reviewer for many scientific journals.

Alberto Zangrillo is a Full Professor of Anesthesiology and Intensive Care, Head of Dept. of Anesthesia and Intensive Care at San Raffaele Scientific Institute and Vita-Salute San Raffaele University, and Vice-rector for clinical activities at Vita-Salute San Raffaele, Milan, Italy, the largest Italian surgical hospital. Dr. Zangrillo is among the world’s top 10 fastest publishing clinical scientists in the field of anesthesia and the author of more than 500 scientific publications on intensive care (H index of 33). He has participated as principal investigator in 32 randomized controlled trials. He was decorated with the title of Knight of the Order of Merit of the Italian Republic by the President of the Republic in June 2004 and with the title of Commander by President of the Republic Giorgio Napolitano in December 2010.


Bibliographic information


“Reducing Mortality in the Perioperative Period, Second Edition provides an easy to read, complete, up-to-date summary of interventions that influence perioperative mortality. This book can be recommended to every perioperative physician who needs a comprehensive, quick overview of current evidence-based interventions in perioperative medicine.” (Olga C. P. van der Woude and Jan M. Dieleman, Canadian Journal of Anesthesia/Journal canadien d'anesthésie, November, 2017)

“This is a concise and precise collection of interventions that are known to impact perioperative survival. It is in a class of its own. Of all the books that claim to provide information that can help readers become better clinicians, only this one meets the challenge. It's a must read for every anesthesiologist, internist, and surgeon regardless of their experience or training.” (Tariq M. Malik, Doody's Book Reviews, November, 2017)

“This book details the process by which the relevant interventions were identified and researched in detail, followed by an in-depth look at the 13 treatment modalities in question. … This book is a thoroughly useful reference guide for those working within the field of perioperative medicine, bringing together a wealth of useful clinical information into a handy compendium.” (Harjot Singh and Ryan O’Leary, Anesthesia & Analgesia, Vol. 125 (4), October, 2017)