Resistance to Targeted Therapies Against Adult Brain Cancers

  • Amanda Tivnan

Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Shane M. Crilly, Philip J. O’Halloran
    Pages 1-23
  3. Han Shen, Eric Hau
    Pages 55-68
  4. Richard Hill, Samantha A. Murray, Zaynah Maherally, Samantha C. Higgins, Geoffrey J. Pilkington
    Pages 107-144
  5. Jenny L. Pokorny, Gaspar J. Kitange, Daniel J. Ma
    Pages 145-174
  6. Kate Connor, Monika A. Jarzabek, Kieron White, Andreas H. Jacobs, Annette T. Byrne
    Pages 175-198
  7. Kyle A. Smith, Chris Miller, Domenico Gattozzi, Roukoz B. Chamoun
    Pages 199-217
  8. Back Matter
    Pages 255-260

About this book


This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.


Brain cancer Brain tumors Malignant Glioblastoma Drug resistance

Editors and affiliations

  • Amanda Tivnan
    • 1
  1. 1.Centre for Systems Medicine, Department of Physiology and Medical PhysicsRoyal College of Surgeons in IrelandDublinIreland

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-46504-3
  • Online ISBN 978-3-319-46505-0
  • Series Print ISSN 2196-5501
  • Series Online ISSN 2196-551X
  • Buy this book on publisher's site