The Pathology of Cardiac Transplantation

A clinical and pathological perspective

  • Ornella Leone
  • Annalisa Angelini
  • Patrick Bruneval
  • Luciano Potena

Table of contents

  1. Front Matter
    Pages i-xx
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Margaret Burke, Luciano Potena
      Pages 3-10
  3. Prior to Cardiac Transplantation

    1. Front Matter
      Pages 11-11
    2. John Parissis, Spyridon Katsanos, Sergei Pepoyan, Gerasimos Filippatos
      Pages 13-20
    3. Alexander Stepanenko, Evgenij Potapov, Volkmar Falk, Thomas Krabatsch
      Pages 21-32
    4. Francesco Tona, Carlo Dal Lin
      Pages 33-40
    5. Ornella Leone, Annalisa Angelini, Marny Fedrigo, Aryan Vink, Allard van der Wal
      Pages 41-99
  4. Heart Donation and Peritransplant Pathologies

    1. Front Matter
      Pages 113-113
    2. Ornella Leone, Luciano Potena, Alberto Foà, Andreas Zuckermann
      Pages 115-135
    3. Jonida Bejko, Giuseppe Feltrin, Annalisa Angelini, Gino Gerosa
      Pages 137-145
    4. Annalisa Angelini, Marny Fedrigo
      Pages 147-152
  5. Post-cardiac Transplantation: The Multiple Faces of Rejection

    1. Front Matter
      Pages 153-153
    2. Luciano Potena, Valentina Manfredini, Ornella Leone
      Pages 155-169
    3. Marco Masetti, Francesco Grigioni
      Pages 171-184
    4. John D. Smith, Marlene L. Rose
      Pages 185-198
    5. Desley A. H. Neil, Alexandra J. Rice
      Pages 199-217
    6. Samuel Rotman, Dylan V. Miller, Claire Toquet, Gerald J. Berry
      Pages 219-242
    7. Dylan V. Miller, Abdallah G. Kfoury
      Pages 243-250
    8. Helen Doran, Desley A. H. Neil
      Pages 251-263
    9. Marie-Claude Parent, Brian A. Clarke, Kiran K. Khush
      Pages 265-277
    10. Marny Fedrigo, Jorge Pombo Otero, Francesco Tona, Carlo Dal Lin, Marisa Crespo Leiro, Patrick Bruneval
      Pages 279-305
  6. Post-cardiac Transplantation: Complications Other than Rejection

    1. Front Matter
      Pages 307-307
    2. David Lebeaux, Julien Coussement, Sylvain Poiree, Olivier Lortholary
      Pages 309-327
    3. Valentina Agostini, Heike Goebel, Luciano Potena, Gerald J. Berry, Ornella Leone
      Pages 329-352
    4. Gaia Magnani, Marialuisa Valente, Francesco Marchini
      Pages 353-364
  7. Special Issues in Cardiac Transplantation

    1. Front Matter
      Pages 365-365
    2. Jean-Paul Duong Van Huyen, Franck Iserin, Claire Toquet
      Pages 367-377
    3. Martin Goddard
      Pages 379-391
    4. Annalisa Angelini, Marny Fedrigo, Margaret Burke
      Pages 393-417
  8. Back Matter
    Pages 427-450

About this book


This is the first book to focus entirely on the role of pathology in cardiac transplantation, linked to the clinical perspective through clinical–pathological correlation, multidisciplinary team working, and collaborative research. It provides a scientific framework with up-to-date pathological protocols and classification schemes and guides the reader through the chronological phases of the transplant process in a step-by-step approach. Topics include end-stage heart failure with pathologies encountered in the native heart, current issues surrounding donor selection, the multiple faces of rejection pathology correlated with clinical management and immunology, other post-transplant complications, details of pediatric and combined heart/other organ transplantation, and a useful practical appendix. Many high-quality images and illustrative cases are presented, along with learning points and ample references.

Transplantation medicine today is continuously changing as collaborative research into novel diagnostic techniques and immunosuppressive therapies translates into improved recipient management and survival. This book is aimed at practicing transplant pathologists and specialist trainees. It will also appeal to general pathologists and to physicians and surgeons involved in cardiac transplantation who need to understand the role of pathology in the clinical management of transplant recipients.


allograft vasculopathy endomyocardial biopsy heart disease heart donor rejection

Editors and affiliations

  • Ornella Leone
    • 1
  • Annalisa Angelini
    • 2
  • Patrick Bruneval
    • 3
  • Luciano Potena
    • 4
  1. 1.Cardiovascular and Cardiac Transplant Pathology Program Department of PathologySant’Orsola-Malpighi University HospitalBolognaItaly
  2. 2.Pathology of Cardiac Transplantation and Regenerative Medicine Unit Department of Cardiac Thoracic and Vascular SciencesUniversity of PaduaPaduaItaly
  3. 3.Department of PathologyHôpital Européen Georges PompidouParisFrance
  4. 4.Heart Failure and Heart Transplant Program, Cardiology UnitSant’Orsola-Malpighi University HospitalBolognaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-46384-1
  • Online ISBN 978-3-319-46386-5
  • Buy this book on publisher's site