The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease

Cushing’s Syndrome and Beyond

  • Eliza B. Geer

Table of contents

  1. Front Matter
    Pages i-vi
  2. Hypothalamic-Pituitary-Adrenal Axis Regulation of the Body, Brain, and Inflammation

    1. Front Matter
      Pages 1-1
    2. Alexandria Atuahene Opata, Khadeen C. Cheesman, Eliza B. Geer
      Pages 3-26
    3. Alberto M. Pereira, Onno C. Meijer
      Pages 27-41
    4. Maria G. Petrillo, Carl D. Bortner, John A. Cidlowski
      Pages 43-63
  3. Cushing’s Syndrome

    1. Front Matter
      Pages 65-65
    2. Nada El Ghorayeb, Isabelle Bourdeau, André Lacroix
      Pages 67-92
    3. Lynnette K. Nieman, Ahmed M. Gharib
      Pages 137-148
    4. Hekmat Zarzour, Margaret Pain, Joshua Bederson, Kalmon D. Post
      Pages 149-164
    5. Nicholas A. Tritos, Beverly M. K. Biller
      Pages 165-179
    6. Adina F. Turcu, Richard J. Auchus
      Pages 181-197
    7. Anna Aulinas, Elena Valassi, Eugenia Resmini, Alicia Santos, Iris Crespo, María-José Barahona et al.
      Pages 199-224
    8. Jeremy N. Ciporen, Justin S. Cetas, Shirley McCartney, Maria Fleseriu
      Pages 225-252
  4. Beyond Cushing’s: Glucocorticoid Sensitivity, Regulation, and the Metabolic Syndrome

    1. Front Matter
      Pages 253-253
    2. Nicolas C. Nicolaides, Agaristi Lamprokostopoulou, Amalia Sertedaki, George P. Chrousos, Evangelia Charmandari
      Pages 255-269
    3. Emilia Sbardella, Jeremy W. Tomlinson
      Pages 271-301
    4. Vincent L. Wester, Elisabeth F. C. van Rossum
      Pages 303-313
  5. Back Matter
    Pages 315-327

About this book


Cushing´s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing’s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing’s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.


HPA axis adrenal cortisol metabolic disorders neuroendocrine pathophysiology

Editors and affiliations

  • Eliza B. Geer
    • 1
  1. 1.Division of EndocrinologyMultidisciplinary Pituitary and Skull Base Tumor Center, Memorial Sloan Kettering Cancer CenterNew YorkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-45948-6
  • Online ISBN 978-3-319-45950-9
  • Buy this book on publisher's site