The Science and Practice of Lithium Therapy

  • Gin S. Malhi
  • Marc Masson
  • Frank Bellivier

Table of contents

  1. Front Matter
    Pages i-xvi
  2. The Science of Lithium

    1. Front Matter
      Pages 1-1
    2. Dominique Larcher, Jean-Marie Tarascon
      Pages 3-23
    3. Camille Couffignal, Lucie Chevillard, Souleiman El Balkhi, Salvatore Cisternino, Xavier Declèves
      Pages 25-53
    4. Alessio Squassina, Claudia Pisanu, Martin Alda
      Pages 77-96
    5. Josselin Houenou, Chloé Benizri, Barbara Jakubowicz
      Pages 97-109
    6. Pierre Alexis Geoffroy, Bruno Etain
      Pages 111-124
    7. Thomas Mauras, Sarah Sportiche, Sami Richa, Marc Masson
      Pages 125-140
    8. Alexandre Dayer, Nader Perroud, Jean-Michel Aubry
      Pages 141-155
    9. Frank Bellivier, Cynthia Marie-Claire
      Pages 157-178
  3. Lithium in Practice

    1. Front Matter
      Pages 179-179
    2. Marc-Louis Bourgeois, Marc Masson
      Pages 181-188
    3. Gin S. Malhi, Danielle Gessler, Kristina Fritz, Christine Allwang, Tim Outhred, Pritha Das
      Pages 189-209
    4. Chantal Henry, Aroldo A. Dargél, Jan Scott
      Pages 211-222
    5. Helen Jones, John Geddes, Andrea Cipriani
      Pages 223-240
    6. Nicolas Schaad, Jean-Michel Aubry
      Pages 241-247
    7. Rebecca F. McKnight, John R. Geddes, Guy M. Goodwin
      Pages 249-264
    8. Aude Servais, Marc Masson, Jean-Pierre Grünfeld
      Pages 265-276
    9. Souleiman El Balkhi, Bruno Mégarbane
      Pages 277-292
    10. Anne-Laure Sutter-Dallay, Stéphanie Brun
      Pages 293-301
    11. Nathalie Nanzer, Jean-Michel Aubry
      Pages 303-314
    12. Frédéric Limosin, Jean-Pierre Schuster
      Pages 315-321
    13. Guy M. Goodwin
      Pages 323-327
  4. Back Matter
    Pages 329-342

About this book


This book provides a clear and comprehensive guide to the clinical prescription of lithium that draws upon evidence-based knowledge of its mechanisms of action. The book is divided into two parts, on the science of lithium and the practice of lithium therapy. The former covers aspects such as the properties of the lithium ion, pharmacokinetics and pharmacodynamics, impact on neurotransmission, and gene expression modulation. The section on practice includes discussion of variability in response to lithium, use of lithium in the treatment of bipolar disorders, its value in suicide prevention, administration during pregnancy and in the pediatric age group, and side effects.

Lithium is arguably the only true mood stabilizer, and its multifaceted effects across many clinical domains have given rise to a resurgence of interest in recent years, fuelled by both researchers and clinicians. Nevertheless, its use remains constrained by exaggerated concerns about potential side-effects. In reality, lithium is a simple molecule that is relatively straightforward to administer and monitor and has potentially profound benefits at a fraction of the cost of contemporary agents. This book dispels the many myths and concerns that surround its use and will be of interest for clinicians and researchers worldwide.


Bipolar Disorders Lithium Lithium Ion Lithium in Bipolar Disorder Mood Stabilizer Neurobiological Pathways Pharmacodynamics of Lithium Pharmacokinetics of Lithium Psychopharmacology Mania Depression Suicide Neuroprotection Augmentaton Therapy Manic-Depressive Illness

Editors and affiliations

  • Gin S. Malhi
    • 1
  • Marc Masson
    • 2
  • Frank Bellivier
    • 3
  1. 1.Academic Department of PsychiatrySydney Medical School The University of SydneySydneyAustralia
  2. 2.Nightingale Hospitals Paris-Clinique du Château de Garches, Consultant Service Hospitalo-Universitaire Centre Hospitalier Sainte-AnneParisFrance
  3. 3.Publique – Hôpitaux de ParisINSERM UMR-S1144 Paris-Diderot UniversityParisFrance

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-45921-9
  • Online ISBN 978-3-319-45923-3
  • Buy this book on publisher's site