Ex Vivo Engineering of the Tumor Microenvironment

  • Amir R. Aref
  • David Barbie

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Russell W. Jenkins
    Pages 1-12
  3. Dennis O. Adeegbe, Yan Liu
    Pages 13-40
  4. Israel Cañadas, David A. Barbie
    Pages 41-54
  5. Samira Jamalian, Mohammad Jafarnejad, Amir R. Aref
    Pages 55-70
  6. Bee Luan Khoo, Parthiv Kant Chaudhuri, Chwee Teck Lim, Majid Ebrahimi Warkiani
    Pages 71-94
  7. Michaela Bowden
    Pages 95-120
  8. Babak Behnam, Hassan Fazilaty, Ali Roghanian
    Pages 121-135

About this book


This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.


Ex Vivo Reconstruction Solid Tumors Therapeutics Tumor

Editors and affiliations

  • Amir R. Aref
    • 1
  • David Barbie
    • 2
  1. 1.Department of Medical OncologyDana-Farber Cancer InstituteBostonUSA
  2. 2.Department of Medical OncologyDana-Farber Cancer InstituteBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-45395-8
  • Online ISBN 978-3-319-45397-2
  • Series Print ISSN 2196-9906
  • Series Online ISSN 2196-9914
  • Buy this book on publisher's site