Neuroprotective Therapy for Stroke and Ischemic Disease

  • Paul A. Lapchak
  • John H. Zhang

Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Stroke Neuroprotection: The History and Learning Experience

    1. Front Matter
      Pages 1-1
    2. Sarah K. McCann, Emily S. Sena, Gillian L. Currie, Malcolm R. Macleod, David W. Howells
      Pages 73-93
    3. Donald J. DeGracia, Doaa Taha, Fika Tri Anggraini, Zhifeng Huang
      Pages 95-122
    4. Victoria E. O’Collins
      Pages 123-131
    5. Ali Razmara, Steven C. Cramer
      Pages 133-154
  3. Novel Neuroprotection Mechanisms and Targets

    1. Front Matter
      Pages 155-155
    2. Linda M. Haugaard-Kedström, Eduardo F. A. Fernandes, Kristian Strømgaard
      Pages 157-184
    3. Anders Bach
      Pages 203-250
    4. Alejandro Escobar-Peso, Mourad Chioua, Valerio Frezza, Emma Martínez-Alonso, José Marco-Contelles, Alberto Alcázar
      Pages 251-283
    5. Diana Amantea, Rosaria Greco, Cristina Tassorelli, Giacinto Bagetta
      Pages 303-328
    6. Morgane Louessard, Eloise Lemarchand, Carine Ali, Denis Vivien, Benoit Denis Roussel
      Pages 329-348
    7. Roberto Federico Villa, Federica Ferrari, Antonio Moretti
      Pages 349-399
    8. Sergio Amaro, Xabier Urra, Ángel Chamorro
      Pages 401-414
    9. Hong-Shuo Sun, Zhong-Ping Feng
      Pages 415-432
    10. Victor V. Uteshev
      Pages 433-457
    11. Roy Poblete, Gene Sung
      Pages 477-499
    12. Steven L. Gogela, Todd A. Abruzzo, Mario Zuccarello
      Pages 501-526
    13. JungSeok Lee, Mark Fisher
      Pages 527-536
    14. Ain A. Neuhaus, Brad A. Sutherland, Alastair M. Buchan
      Pages 537-556
  4. Thrombolysis and Embolectomy

    1. Front Matter
      Pages 557-557
    2. Hormozd Bozorgchami, Helmi L. Lutsep
      Pages 559-591
    3. Georgios Tsivgoulis, Apostolos Safouris, Andrei V. Alexandrov
      Pages 593-606
    4. Burak Yulug, Wolf-Rüdiger Schäbitz
      Pages 607-620
    5. Jennifer L. H. Johnson
      Pages 621-640
    6. Natacha Le Moan, Philberta Y. Leung, Natalia Rost, Jonathan A. Winger, Ana Krtolica, Stephen P. Cary
      Pages 641-664
  5. Stroke Models and Clinical Trial Considerations

    1. Front Matter
      Pages 665-665
    2. Daisy Chou, Anja Muehle, Paul A. Lapchak, Ali Khoynezhad
      Pages 689-700
    3. Claire L. Gibson, Philip M. W. Bath, Raeed Altaee
      Pages 701-709
    4. I. Sebastião, E. Candeias, M. S. Santos, C. R. Oliveira, Paula I. Moreira, Ana I. Duarte
      Pages 711-731
    5. Anjali Chauhan, Hope Moser, Louise D. McCullough
      Pages 733-750
  6. Back Matter
    Pages 775-795

About this book


This book is a critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in both academia and industry; it serves to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently, stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. Divided into five sections, the proposed volume explores historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the most recent bench-side research.


CNS disorders thrombolysis oxidative stress excitotoxicity sex-specific

Editors and affiliations

  • Paul A. Lapchak
    • 1
  • John H. Zhang
    • 2
  1. 1.Department of Neurology and NeurosurgeryCedars-Sinai Medical CenterLos AngelesUSA
  2. 2.Loma Linda University School of MedicineLoma LindaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-45344-6
  • Online ISBN 978-3-319-45345-3
  • Series Print ISSN 2363-958X
  • Series Online ISSN 2363-9598
  • Buy this book on publisher's site