Systems Pharmacology and Pharmacodynamics

  • Donald E. Mager
  • Holly H.C. Kimko

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 23)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Systems Modeling

    1. Front Matter
      Pages 1-1
    2. Donald E. Mager, Holly H. C. Kimko
      Pages 3-14
    3. Vikram Sinha, Shiew-Mei Huang, Darrell R. Abernethy, Yaning Wang, Ping Zhao, Issam Zineh
      Pages 15-25
    4. Saroja Ramanujan, Kapil Gadkar, Ananth Kadambi
      Pages 27-52
    5. Marc R. Birtwistle, Jens Hansen, James M. Gallo, Sreeharish Muppirisetty, Peter Man-Un Ung, Ravi Iyengar et al.
      Pages 53-80
    6. Steven Nathaniel Steinway, Rui-Sheng Wang, Reka Albert
      Pages 81-103
    7. Mehdi Bouhaddou, Marc R. Birtwistle
      Pages 105-135
    8. Michael C. K. Khoo, Wen-Hsin Hu, Patjanaporn Chalacheva
      Pages 137-158
  3. Pharmacodynamics

    1. Front Matter
      Pages 159-159
    2. William J. Jusko
      Pages 161-175
    3. Alberto Russu, Italo Poggesi
      Pages 211-227
    4. Yaping Zhang, David Z. D’Argenio
      Pages 229-253
    5. Peter L. Bonate, Amit Desai, Ahsan Rizwan, Zheng Lu, Stacey Tannenbaum
      Pages 255-276
  4. Multi-scale Models of Drug Action

    1. Front Matter
      Pages 303-303
    2. Hugo Geerts, Patrick Roberts, Athan Spiros, Robert Carr
      Pages 305-324
    3. Jeremy D. Scheff, Kubra Kamisoglu, Ioannis P. Androulakis
      Pages 325-352
    4. Yoshiaki Kariya, Masashi Honma, Hiroshi Suzuki
      Pages 353-370
    5. Gauri G. Rao, Neang S. Ly, Brian T. Tsuji, Jürgen B. Bulitta, Alan Forrest
      Pages 371-402
    6. James R. Bosley, Tristan S. Maurer, Cynthia J. Musante
      Pages 465-507
  5. Back Matter
    Pages 509-511

About this book


While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.


PK/PD bioinformatics drug targets modeling pharmacokinetics systems biology

Editors and affiliations

  • Donald E. Mager
    • 1
  • Holly H.C. Kimko
    • 2
  1. 1.Department of Pharmaceutical SciencesUniversity at Buffalo, SUNYBuffaloUSA
  2. 2.Global Clinical PharmacologyJanssen Research and Development, LLC,Spring HouseUSA

Bibliographic information