Herpes Zoster: Postherpetic Neuralgia and Other Complications

Focus on Treatment and Prevention

  • C. Peter N. Watson
  • Anne A. Gershon
  • Michael N. Oxman

Table of contents

  1. Front Matter
    Pages i-xxxix
  2. C. Peter N. Watson
    Pages 1-4
  3. Varicella (Chickenpox)

    1. Front Matter
      Pages 5-5
    2. Anne A. Gershon
      Pages 7-15
  4. Herpes Zoster (Shingles)

    1. Front Matter
      Pages 17-17
    2. Anne Tuzi, C. Peter N. Watson
      Pages 19-23
    3. Emma Davies, James Chodosh, Deborah Pavan-Langston
      Pages 45-59
    4. Maija Haanpää
      Pages 61-75
    5. Maria A. Nagel, Don Gilden
      Pages 77-84
    6. Charlotte Warren-Gash, Judith Breuer
      Pages 85-96
    7. Ranjani Somayaji, James A. Elliott, R. Gary Sibbald
      Pages 103-115
  5. Postherpetic Neuralgia: Assessment, Pathology, Pathophysiology

  6. Postherpetic Neuralgia: Treatment

    1. Front Matter
      Pages 227-227
    2. Ralf Baron, Paul Möller, Philipp Hüllemann
      Pages 229-238
    3. Shane E. Brogan, Perry G. Fine
      Pages 239-251
  7. The Prevention of Herpes Zoster and Postherpetic Neuralgia

    1. Front Matter
      Pages 333-333
    2. C. Peter N. Watson
      Pages 335-339
    3. Sigrun Alba Johannesdottir Schmidt, Michael C. Rowbotham
      Pages 341-364
    4. Michael N. Oxman, Ruth Harbecke
      Pages 365-418
    5. C. Peter N. Watson
      Pages 419-419
  8. Back Matter
    Pages 421-431

About this book


Representing a state-of-the-art appraisal of this viral infection and its complications, this book comprises contributions from international authorities in infectious diseases and neuropathic pain. Important new information is presented on the role of the virus in terms of vascular risk, notably in heart attack, stroke and granulomatous angiitis (temporal arteritis). Similarly, new information on gastrointestinal involvement, often in the absence of rash and as seen with vasculopathies, is covered. The reader will benefit from new research into the pathology, pathophysiology and treatment of postherpetic neuralgia and its complications, and special attention is paid to prevention through zoster vaccination using the current vaccine, and a novel, broader option that can be used in immunocompromised patients.

This books follows the two editions of the book, Herpes Zoster and Postherpetic Neuralgia, and is divided into sections for the convenience of the reader.  A section on herpes zoster includes epidemiology and natural history of the varicella zoster virus, herpes zoster ophthalmicus, neurological complications, the role of varicella zoster virus  in giant cell arteritis, concern about increased vascular risk of heart attack and stroke, antiviral therapy, and treatment of skin manifestations.  A section on postherpetic neuralgia includes important information on the effect of herpes zoster and postherpetic neuralgia on quality of life, the neuropathology and pathophysiological mechanisms in postherpetic neuralgia, and the new concept of persistent ganglionitis as the cause of postherpetic neuralgia.  A comparison is made between facial postherpetic neuralgia and trigeminal neuralgia.  There is an extensive section on treatment, including the role of opioids, the general treatment of postherpetic neuralgia, intervention and neurosurgical approaches, and covering guidelines for clinical trial designs in postherpetic neuralgia.  A final section addresses the questions of whether aggressive treatment of acute herpes zoster can prevent postherpetic neuralgia and includes a critically important chapter on herpes zoster vaccines.


Antiviral Therapy Clinical Trial Design Epidemiology Giant Cell Arteritis Health-Related Quality of Life Herpes Zoster Ophthalmicus Interventional Approaches Myocardial Infarction Neurological Complications Neuropathology Neurosurgical Approaches Pathophysiology Stroke The role of opioids Skin Lesions Varicella Zoster Virus Zoster vaccine Live attenuated Oka VZV vaccines

Editors and affiliations

  • C. Peter N. Watson
    • 1
  • Anne A. Gershon
    • 2
  • Michael N. Oxman
    • 3
  1. 1.Department of MedicineUniversity of Toronto Department of MedicineTORONTOCanada
  2. 2.College of Physicians & SurgeonsColumbia University College of Physicians & SurgeonsNew YorkUSA
  3. 3.Department of Medicine, Division of Infectious DiseasesUniversity of CaliforniaSan Diego, La JollaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Adis, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-44346-1
  • Online ISBN 978-3-319-44348-5
  • Buy this book on publisher's site