Immunotherapy for Pediatric Malignancies

  • Juliet C. Gray
  • Aurélien Marabelle

Table of contents

  1. Front Matter
    Pages i-ix
  2. Aurélien Marabelle, Claudia Rossig
    Pages 1-11
  3. Patrick Schlegel, Christian Seitz, Peter Lang, Rupert Handgretinger
    Pages 39-64
  4. Juliet C. Gray, Paul M. Sondel
    Pages 65-78
  5. Matthew J. Barth, Jessica Hochberg, Nader Kim El-Mallawany, Mitchell S. Cairo
    Pages 79-116
  6. Véronique Minard-Colin
    Pages 141-160
  7. Jonathan Fisher, John Anderson
    Pages 161-174
  8. Kenneth DeSantes, Kimberly McDowell
    Pages 175-215
  9. Miho Nakajima, Shakeel Modak
    Pages 217-242
  10. Vito Pistoia, Ignazia Prigione, Lizzia Raffaghello
    Pages 243-257
  11. Michaela Semeraro, Claudia Pasqualini, Nathalie Chaput
    Pages 259-273
  12. Aurelien Marabelle, Juliet C. Gray
    Pages 275-289
  13. Back Matter
    Pages 291-297

About this book


This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy.

Edited by two distinguished pediatric oncologists with a collection of chapters from the most authoritative experts in cancer immunotherapy, this is an indispensable volume for pediatric oncologists and physicians working in childhood cancer care.


Allogeneic Stem Cell Transplantation Monoclonal Antibody T-cell therapy cancer cytokine immunotherapy pediatrics tumour microenvironment vaccine therapy

Editors and affiliations

  • Juliet C. Gray
    • 1
  • Aurélien Marabelle
    • 2
  1. 1.Cancer Sciences UnitUniversity of SouthamptonSouthamptonUnited Kingdom
  2. 2.Département d’Innovation Thérapeutique et d'Essais PrécocesUniversity of Paris-Saclay Gustave RoussyVillejuifFrance

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-43484-1
  • Online ISBN 978-3-319-43486-5
  • Buy this book on publisher's site