The Ageing Immune System and Health

  • Valquiria Bueno
  • Janet M. Lord
  • Thomas A. Jackson

Table of contents

  1. Front Matter
    Pages i-xii
  2. Mohammad Ahsan Tariq, Jon Hazeldine, Janet M. Lord
    Pages 1-20
  3. Lisa M. McEwen, Sarah J. Goodman, Michael S. Kobor, Meaghan J. Jones
    Pages 35-52
  4. Ludmila Müller, Klaus Hamprecht, Graham Pawelec
    Pages 53-68
  5. Birgit Weinberger
    Pages 69-86
  6. Krisztian Kvell, Judit E. Pongracz
    Pages 87-104
  7. Nora Manoukian Forones, Valquiria Bueno
    Pages 105-124
  8. Thomas A. Jackson, Daisy Wilson, Carolyn A. Greig
    Pages 141-159
  9. David B. Bartlett, Kim M. Huffman
    Pages 161-176
  10. Back Matter
    Pages 177-182

About this book


The present book intends to provide an update on immunosenescence and how deficiencies in the immune system contribute to a higher susceptibility to infections, decline in organ function, reduced vaccination responses, age-related disease and the ageing process itself, negatively affecting longevity. Our focus is on the main changes in immune system cells and their products occurring during the ageing process and the possible consequences for health and disease. This includes: discussion of the modulatory and/or suppressive mechanisms associated with the alterations in T regulatory cells, B regulatory cells and Myeloid Derived Suppressor cells; changes in the immune system observed in chronic neurodegenerative diseases, cancer, lung disease and frailty will also be discussed. Most importantly we provide recent literature information about possible interventions (focusing on physical activity) that could alleviate the negative effects of immunosenescence.
The Ageing Immune System and Health is a comprehensive guide on the field intended to all physicians, researchers, professors and students interested on relationship between immune system, ageing and health. 


Age-related diseases Ageing Elderly Immune system Immunosenescence

Editors and affiliations

  • Valquiria Bueno
    • 1
  • Janet M. Lord
    • 2
  • Thomas A. Jackson
    • 3
  1. 1.Department of MicrobiologyImmunology and Parasitology UNIFESP Federal University of São PauloSao PauloBrazil
  2. 2.MRC-ARUK Centre for Musculoskeletal Ageing ResearchInstitute of Inflammation and Ageing Birmingham University Medical School BirminghamBirminghamUnited Kingdom
  3. 3.Institute of Inflammation and AgeingUniversity of Birmingham University of Birmingham Research LaboratoriesBirminghamUnited Kingdom

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-43363-9
  • Online ISBN 978-3-319-43365-3
  • Buy this book on publisher's site