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The Role of Pendrin in Health and Disease

Molecular and Functional Aspects of the SLC26A4 Anion Exchanger

  • Silvia Dossena
  • Markus Paulmichl

Table of contents

  1. Front Matter
    Pages i-x
  2. Silvia Dossena, Markus Paulmichl
    Pages 1-4
  3. The Role of Pendrin in the Inner Ear

    1. Front Matter
      Pages 5-5
    2. Philine Wangemann, Andrew J. Griffith
      Pages 7-22
    3. Sebastian Roesch, Miklós Tóth, Gerd Rasp
      Pages 37-60
    4. Sueli Matilde da Silva Costa, Priscila Zonzini Ramos, Fábio Tadeu Arrojo Martins, Edi Lúcia Sartorato
      Pages 61-81
  4. The Role of Pendrin in the Thyroid

    1. Front Matter
      Pages 83-83
    2. Gregor Schweighofer Zwink, Christian Pirich
      Pages 85-105
  5. The Role of Pendrin in the Kidney

    1. Front Matter
      Pages 119-119
  6. The Role of Pendrin in the Airways

    1. Front Matter
      Pages 139-139
    2. Kenji Izuhara, Shoichi Suzuki, Charity Nofziger, Masahiro Ogawa, Shoichiro Ohta, Yasuhiro Nanri et al.
      Pages 141-154
  7. The Pendrin Gene and Protein

    1. Front Matter
      Pages 155-155
    2. Julia Rozenfeld, Charity Nofziger, Orly Kladnitsky, Seth L. Alper, Israel Zelikovic
      Pages 157-185
    3. Silvia Dossena, Emanuele Bernardinelli, Alok K. Sharma, Seth L. Alper, Markus Paulmichl
      Pages 187-220
  8. Back Matter
    Pages 221-226

About this book

Introduction

This book reviews the current state of knowledge on the genetics, molecular biology and physiology of pendrin, with a particular focus on pendrin dysfunction and the consequences for human health. 

Pendrin is a membrane transport protein expressed in the thyroid, inner ear, kidney and airways, and was recently found in a variety of other tissues and organs. Pendrin malfunction may cause a genetic disease called Pendred syndrome or non-syndromic deafness.

The book provides a thorough description of the multifaceted role of pendrin in human health and disease. As such, it offers an invaluable tool for physiology and pathology researchers, while also providing essential guidance for otorhinolaryngologists and endocrinologists in the diagnosis of Pendred syndrome and pendrin-related deafness.

Keywords

Deafness Enlarged Vestibular Aqueduct Pendred syndrome Pendrin SLC26A4 Thyroid dysfunction

Editors and affiliations

  • Silvia Dossena
    • 1
  • Markus Paulmichl
    • 2
  1. 1.Paracelsus Medical University Institute of Pharmacology and ToxicologySalzburgAustria
  2. 2.Paracelsus Medical University Institut of Pharmacology and ToxicologySalzburgAustria

Bibliographic information