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Molecular Pathology of Breast Cancer

  • Sunil Badve
  • Yesim Gökmen-Polar

Table of contents

  1. Front Matter
    Pages i-viii
  2. Lisa Meier McShane, Tracy G. Lively, Hala R. Makhlouf
    Pages 1-18
  3. Anthony Warford, Bharat Jasani
    Pages 27-43
  4. K. P. M. Suijkerbuijk, E. van der Wall, P. J. van Diest
    Pages 45-58
  5. Cesar Santa-Maria, Sarika Jain, William J. Gradishar
    Pages 59-70
  6. Melinda L. Telli
    Pages 71-80
  7. Frederique Penault-Llorca, Nina Radosevic-Robin
    Pages 81-98
  8. Emad A. Rakha, Ian O. Ellis
    Pages 99-119
  9. Sunil Badve
    Pages 121-132
  10. Dong Soon Choi, Roberto R. Rosato, Jenny C. Chang
    Pages 133-151
  11. Joseph A. Sparano, Joan Jones, Thomas E. Rohan, Allison S. Harney, John Condeelis, Maja H. Oktay
    Pages 153-165
  12. Murali Janakiram, Hina Khan, Susan Fineberg, Xingxing Zang, Joseph A. Sparano
    Pages 167-186
  13. Christine E. Edmonds, David A. Mankoff
    Pages 187-206
  14. Dhivya Prabhakar, Lyndsay Harris
    Pages 207-218
  15. Malgorzata Banys-Paluchowski, Helen Schneck, Natalia Krawczyk, Tanja Fehm
    Pages 219-234
  16. Isabelle Gingras, Libero Santarpia, Michail Ignatiadis
    Pages 235-256
  17. Thomas Karn, Christos Hatzis
    Pages 283-298
  18. Shridar Ganesan, Kim M. Hirshfield
    Pages 299-328
  19. Mukesh Verma, Sunil Badve
    Pages 329-344
  20. Yesim Gökmen-Polar, Sunil Badve
    Pages 345-364
  21. Yesim Gökmen-Polar
    Pages 365-377
  22. Mark Abramovitz, Casey Williams, Brian Leyland-Jones
    Pages 379-401
  23. Xianyin Lai, S. Badve
    Pages 403-414
  24. Lida Mina, George W. Sledge
    Pages 415-426
  25. Back Matter
    Pages 427-428

About this book

Introduction

The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine.  

The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques.

The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated  to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics,

“Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer. 


Keywords

Breast Cancer Molecular markers Biomarkers Pathobiology Precision medicine

Editors and affiliations

  • Sunil Badve
    • 1
  • Yesim Gökmen-Polar
    • 2
  1. 1.Pathology & Laboratory MedicineIndiana University School of MedicineIndianapolisUSA
  2. 2.Indiana University School of MedicineDept of Pathology & Laboratory Medicine Indiana University School of MedicineIndianapolisUSA

Bibliographic information