Adhesion G Protein-coupled Receptors

Molecular, Physiological and Pharmacological Principles in Health and Disease

  • Tobias Langenhan
  • Torsten Schöneberg

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 234)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Jörg Hamann, Alexander G. Petrenko
    Pages 1-11
  3. Molecular and Pharmacological Properties of Adhesion GPCRs

    1. Front Matter
      Pages 13-13
    2. Arunkumar Krishnan, Saskia Nijmeijer, Chris de Graaf, Helgi B. Schiöth
      Pages 15-41
    3. Saskia Nijmeijer, Steffen Wolf, Oliver P. Ernst, Chris de Graaf
      Pages 43-66
    4. Demet Araç, Norbert Sträter, Elena Seiradake
      Pages 67-82
    5. Matthias Nieberler, Robert J. Kittel, Alexander G. Petrenko, Hsi-Hsien Lin, Tobias Langenhan
      Pages 83-109
    6. Ines Liebscher, Torsten Schöneberg
      Pages 111-125
    7. Ayush Kishore, Randy A. Hall
      Pages 127-146
    8. Barbara Knapp, Uwe Wolfrum
      Pages 147-178
    9. Peter Kovacs, Torsten Schöneberg
      Pages 179-217
  4. Adhesion GPCRs as Pharmakotargets in Organ Function and Development

    1. Front Matter
      Pages 219-219
    2. Nicole Scholz, Kelly R. Monk, Robert J. Kittel, Tobias Langenhan
      Pages 221-247
    3. David Strutt, Ralf Schnabel, Franziska Fiedler, Simone Prömel
      Pages 249-274
    4. Séverine M. Sigoillot, Kelly R. Monk, Xianhua Piao, Fekrije Selimi, Breanne L. Harty
      Pages 275-298
    5. Marie-Gabrielle Ludwig, Klaus Seuwen, James P. Bridges
      Pages 309-327
    6. Jörg Hamann, Cheng-Chih Hsiao, Chang Sup Lee, Kodi S. Ravichandran, Hsi-Hsien Lin
      Pages 329-350
    7. Gabriela Aust, Dan Zhu, Erwin G. Van Meir, Lei Xu
      Pages 369-396
  5. Saskia Nijmeijer, Steffen Wolf, Oliver P. Ernst, Chris de Graaf
    Pages E1-E1
  6. Back Matter
    Pages 397-403

About this book


Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.


Cell-cell interaction Cell-matrix interaction G protein-coupled receptors Mechanoreception Metabotropic pathways

Editors and affiliations

  • Tobias Langenhan
    • 1
  • Torsten Schöneberg
    • 2
  1. 1.Institute of Physiology Department of NeurophysiologyUniversity of WürzburgWürzburgGermany
  2. 2.Institute of Biochemistry Medical FacultyUniversity of LeipzigLeipzigGermany

Bibliographic information