Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract

  • Marnix Jansen
  • Nicholas A. Wright

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 908)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

    1. Front Matter
      Pages 9-9
    2. Juergen Fink, Bon-Kyoung Koo
      Pages 11-25
    3. James A. Evans, Stuart A. C. McDonald
      Pages 27-40
  3. Cancer Progression in the Distal Esophagus

    1. Front Matter
      Pages 79-79
    2. Anne-Fré Swager, Wouter L. Curvers, Jacques J. Bergman
      Pages 81-98
    3. Myrtle J. van der Wel, Marnix Jansen, Michael Vieth, Sybren L. Meijer
      Pages 137-159
    4. O. J. Old, M. Isabelle, H. Barr
      Pages 161-181
    5. David H. Wang, Rhonda F. Souza
      Pages 183-212
    6. Mark Pusung, Sebastian Zeki, Rebecca Fitzgerald
      Pages 237-263
  4. Cancer Progression in the Stomach

    1. Front Matter
      Pages 291-291
    2. Ichiro Oda, Harushisa Suzuki, Shigetaka Yoshinaga
      Pages 317-330
    3. Shigeki Sekine, Hiroshi Yoshida, Marnix Jansen, Ryoji Kushima
      Pages 331-346
    4. Lodewijk A. A. Brosens, Francis M. Giardiello, G. Johan Offerhaus, Elizabeth A. Montgomery
      Pages 347-369
    5. Rachel S. van der Post, Irene Gullo, Carla Oliveira, Laura H. Tang, Heike I. Grabsch, Maria O’Donovan et al.
      Pages 371-391
    6. Lydia E. Wroblewski, Richard M. Peek Jr.
      Pages 393-408
    7. Marino Venerito, Riccardo Vasapolli, Peter Malfertheiner
      Pages 409-418
    8. Siu Tsan Yuen, Suet Yi Leung
      Pages 419-439
    9. Lin Ding, Mohamad El Zaatari, Juanita L. Merchant
      Pages 441-478
  5. Rachel S. van der Post, Irene Gullo, Carla Oliveira, Laura H. Tang, Heike I. Grabsch, Maria O’Donovan et al.
    Pages E1-E1
  6. Back Matter
    Pages 479-486

About this book


This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett’s esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett’s esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer.

Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer’s Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.


barrett's esophagus esophageal cancer metastasis stomach cancer upper GI

Editors and affiliations

  • Marnix Jansen
    • 1
  • Nicholas A. Wright
    • 2
  1. 1.UCL Cancer InstituteUniversity College LondonLondonUnited Kingdom
  2. 2.Barts Cancer InstituteBarts and the London School of Medicine and DentistryLondonUnited Kingdom

Bibliographic information