© 2017

Research into Childhood-Onset Diabetes

From Study Design to Improved Management

  • Andrea Scaramuzza
  • Carine de Beaufort
  • Ragnar Hanas

Table of contents

  1. Front Matter
    Pages i-viii
  2. Gian Vincenzo Zuccotti
    Pages 1-8
  3. Up-To-Date in Childhood Type 1 Diabetes

    1. Front Matter
      Pages 9-9
    2. M. Loredana Marcovecchio, David B. Dunger
      Pages 39-53
    3. Carine E. de Beaufort, Fergus Cameron, Hilary Hoey, Henrik B. Mortensen
      Pages 55-64
    4. Gianpaolo Zerbini, Silvia Maestroni
      Pages 65-76
    5. Michael C. Riddell, Craig E. Taplin
      Pages 77-89
    6. Simone Franchini, Annalisa Blasetti, Francesco Chiarelli
      Pages 101-113
    7. Dario Iafusco, Santino Confetto, Angela Zanfardino, Alessia Piscopo, Francesca Casaburo, Alessandra Cocca et al.
      Pages 137-146
  4. The Technological Route to the Future

    1. Front Matter
      Pages 147-147
    2. Giulio Maltoni, Stefano Zucchini
      Pages 149-161
    3. Riccardo Bonfanti, Andrea Rigamonti, Giulio Frontino, Roseila Battaglino, Valeria Favalli, Clara Bonura et al.
      Pages 173-181
    4. Carine E. de Beaufort, Bernd Lehmann
      Pages 183-192

About this book


This book offers a detailed update on research into diabetes with onset in childhood or adolescence. The coverage ranges from fundamental aspects such as study design and statistical analysis through to new ideas for research, the latest research findings, and implications of these findings for clinical care in childhood. Examples of topics addressed in this context include the prevention of diabetic complications, management of micro- and macrovascular complications, the roles of nutrition and exercise, insulin therapy, islet transplantation, and risky behaviors in teenagers. Attention is also focused on the latest technologies, including the artificial pancreas and continuous glucose monitoring, and associated regulatory aspects. The reader will find novel insights into the ways in which research is impacting on clinical management as well as advice on methodology and stimulating ideas on future research areas. The book is based on presentations delivered at the 15th ISPAD (International Society for Pediatric and Adolescent Diabetes) Research School for Physicians, held in Milan. It will be of interest for all diabetologists, pediatricians, dietitians, biomedical engineers, nurses, and students.


Exercise Hypoglycemia Insulin therapy Islet transplantation Management of microvascular complications Non-autoimmune diabetes Nutrition Prevention of diabetic complications Risky behaviors Study design

Editors and affiliations

  • Andrea Scaramuzza
    • 1
  • Carine de Beaufort
    • 2
  • Ragnar Hanas
    • 3
  1. 1.Pediatric Diabetology Unit Department of PaediatricsLuigi Sacco HospitalMilanItaly
  2. 2.Luxembourg Centre for Systems BiomedicinUniversité du LuxembourgLuxembourgLuxembourg
  3. 3.Department of PaediatricsUddevalla HospitalUddevallaSweden

About the editors

Andrea E. Scaramuzza is a pediatric diabetologist who works at Luigi Sacco Hospital, University of Milan,  Italy, where he is the Head of Pediatric Diabetology, Metabolic Diseases and Nutrition Unit of the Department of Pediatrics. His work is focused mostly on type 1 diabetes and its management, and he has a particular interest in insulin pump therapy, continuous glucose monitoring, micro- and macrovascular complication screening, and prevention and exercise. He is also a lecturer in Pediatric Endocrinology at the University of Milan. He leads a highly motivated group of young physicians, nurses, dietitians, and psychologists, all of whom are devoted to management of type 1 diabetes in children and adolescents. He is the author of more than 60 papers published in high-impact factor international journals and is the editor and/or reviewer of several journals.


Carine de Beaufort is a research associate at the Luxembourg Centre for Systems Biomedicine, University of Luxembourg (Belval, Luxembourg). After gaining her medical degree and doctorate from the University of Rotterdam, she completed specialization as a pediatrician and then as a pediatric endocrinologist and diabetologist. Upon arrival in Luxembourg, she participated in the creation of a multidisciplinary team (DECCP) for the treatment of children and adolescents with diabetes. Her recent research has focused on the pathophysiology of diabetes (types 1 and 2). She has published more than 80 publications in peer-reviewed journals, as well as several book chapters. In 2012 and 2014 she was Secretary-General of ISPAD (International Society of Pediatric and Adolescent Diabetology).


Ragnar Hanas is a Consultant Pediatrician at Uddevalla Hospital in Sweden and is renowned for his work with children and adolescents with diabetes. He has served as Secretary General of ISPAD and was co-editor of the 2009 ISPAD Clinical Practice Guidelines.  He is author of books on Type 1 and Type 2 diabetes and of several papers.


Bibliographic information

  • Book Title Research into Childhood-Onset Diabetes
  • Book Subtitle From Study Design to Improved Management
  • Editors Andrea Scaramuzza
    Carine de Beaufort
    Ragnar Hanas
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-40240-6
  • Softcover ISBN 978-3-319-82060-6
  • eBook ISBN 978-3-319-40242-0
  • Edition Number 1
  • Number of Pages VIII, 192
  • Number of Illustrations 4 b/w illustrations, 8 illustrations in colour
  • Topics Diabetes
  • Buy this book on publisher's site