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Interleukin-27: Biological Properties and Clinical Application

  • Marek Jankowski
  • Tomasz Wandtke

Part of the SpringerBriefs in Immunology book series (BRIEFSIMMUN)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Marek Jankowski, Tomasz Wandtke
    Pages 1-25
  3. Marek Jankowski, Tomasz Wandtke
    Pages 27-45
  4. Marek Jankowski, Tomasz Wandtke
    Pages 47-86

About this book

Introduction

This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.

Keywords

Cancer Immunotherapy Interleukin-27 receptor Multiple sclerosis Viral infections Rheumatoid arthritis Neoplastic diseases Autoimmune disorders IL-27 Infectious diseases Inflammatory bowel disease COPD Feto-maternal tolerance Autoimmune uveitis Psoriasis Atherosclerosis

Authors and affiliations

  • Marek Jankowski
    • 1
  • Tomasz Wandtke
    • 2
  1. 1.Faculty of Medicine, Chair of DermatologNicolaus Copernicus University in ToruńBydgoszczPoland
  2. 2.Department of Gene TherapyNicolaus Copernicus University in ToruńBydgoszczPoland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-39664-4
  • Copyright Information The Author(s) 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-39662-0
  • Online ISBN 978-3-319-39664-4
  • Series Print ISSN 2194-2773
  • Series Online ISSN 2194-2781
  • Buy this book on publisher's site