Efflux-Mediated Antimicrobial Resistance in Bacteria

Mechanisms, Regulation and Clinical Implications

  • Xian-Zhi Li
  • Christopher A. Elkins
  • Helen I. Zgurskaya

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Bacterial Drug Efflux Pumps: Structures and Transport Mechanisms

    1. Front Matter
      Pages 1-1
    2. Asha V. Nair, Kenneth W. Lee, Hendrik W. van Veen
      Pages 29-44
    3. Denice C. Bay, Raymond J. Turner
      Pages 45-71
    4. Cédric Orelle, Jean-Michel Jault
      Pages 73-98
    5. Helen I. Zgurskaya, Vassiliy N. Bavro, Jon W. Weeks, Ganesh Krishnamoorthy
      Pages 99-128
  3. Bacterial Drug Efflux Pumps in Antimicrobial Resistance: Substrates, Regulation and Clinical Significance

    1. Front Matter
      Pages 129-129
    2. Sylvia A. Sapula, Melissa H. Brown
      Pages 165-195
    3. Natalya Baranova, Christopher A. Elkins
      Pages 197-218
    4. Xian-Zhi Li, Hiroshi Nikaido
      Pages 219-259
    5. Kunihiko Nishino
      Pages 261-279
    6. Anne Davin-Regli, Muriel Masi, Suzanne Bialek, Marie-Hélène Nicolas-Chanoine, Jean-Marie Pagès
      Pages 281-306
    7. Bao-Dong Ling, Li Zhang, Xian-Zhi Li
      Pages 329-358
    8. Xian-Zhi Li, Patrick Plésiat
      Pages 359-400
    9. María B. Sánchez, Guillermo García-León, Alvaro Hernández, José L. Martínez
      Pages 401-416
    10. Viola Camilla Scoffone, Tom Coenye, Giovanna Riccardi, Silvia Buroni
      Pages 417-438
    11. William M. Shafer, Edward W. Yu, Corinne Rouquette-Loughlin, Daniel Golparian, Ann E. Jerse, Magnus Unemo
      Pages 439-469
    12. Lei Dai, Zhangqi Shen, Edward W. Yu, Qijing Zhang
      Pages 471-487
    13. Pedro Eduardo Almeida da Silva, Diana Machado, Daniela Ramos, Isabel Couto, Andrea Von Groll, Miguel Viveiros
      Pages 527-559
    14. Xian-Zhi Li, Manisha Mehrotra
      Pages 595-623
  4. Role of Drug Efflux Pumps Beyond Antimicrobial Resistance: Natural Functions

    1. Front Matter
      Pages 649-649
    2. Alexander Fahmy, Ananth Srinivasan, Mark A. Webber
      Pages 651-663
  5. Antimicrobial Development and Efflux Pump Inhibitors

    1. Front Matter
      Pages 729-729
    2. Jürgen A. Bohnert, Winfried V. Kern
      Pages 755-795
    3. Venkata Krishnan Ramaswamy, Pierpaolo Cacciotto, Giuliano Malloci, Paolo Ruggerone, Attilio V. Vargiu
      Pages 797-831
  6. Back Matter
    Pages 833-848

About this book


This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, AcinetobacterNeisseriaPseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants.


Antibiotic Antimicrobial Multidrug Pump Transporter MDR ABC MATE MFS RND SMR Chromosome Plasmid Enterobacteriaceae Acinetobacter Pseudomonas Staphylococcus Inhibitor Microbiology Pharmacology

Editors and affiliations

  • Xian-Zhi Li
    • 1
  • Christopher A. Elkins
    • 2
  • Helen I. Zgurskaya
    • 3
  1. 1.Health Products and Food BranchHealth CanadaOttawaCanada
  2. 2.U.S. Food and Drug AdministrationLaurelUSA
  3. 3.University of OklahomaNormanUSA

Bibliographic information