The Functional Nucleus

  • David P. Bazett-Jones
  • Graham Dellaire

Table of contents

  1. Front Matter
    Pages i-vi
  2. Nuclear Periphery

    1. Front Matter
      Pages 1-1
  3. Nuclear Bodies

    1. Front Matter
      Pages 27-27
    2. Marie-Line Dubois, François-Michel Boisvert
      Pages 29-49
    3. Michael R. Ladomery, Sebastian Oltean
      Pages 51-69
  4. Chromosomes

    1. Front Matter
      Pages 99-99
    2. Karen J. Meaburn, Bharat Burman, Tom Misteli
      Pages 101-125
    3. Tsz Wai Chu, Chantal Autexier
      Pages 127-154
  5. Nuclear Domains and Development

    1. Front Matter
      Pages 155-155
    2. Vincenzo Pirrotta
      Pages 157-173
    3. Karen E. Brown
      Pages 175-202
  6. Nuclear Domains and Cell Stress

    1. Front Matter
      Pages 203-203
    2. Michael J. Hendzel, Hilmar Strickfaden
      Pages 219-237
    3. Jordan Pinder, Alkmini Kalousi, Evi Soutoglou, Graham Dellaire
      Pages 239-257
    4. Sona Hubackova, Simona Moravcova, Zdenek Hodny
      Pages 259-282
  7. Macromolecular Dynamics Within the Nucleus

    1. Front Matter
      Pages 313-313
    2. Guillaume Huet, Maria K. Vartiainen
      Pages 315-328
    3. Alexander Gansen, Jörg Langowski
      Pages 329-356
  8. Chromatin Transactions and Epigenetics

    1. Front Matter
      Pages 357-357
    2. Christopher J. F. Cameron, James Fraser, Mathieu Blanchette, Josée Dostie
      Pages 359-383
    3. Sebastian Müller, Dan Filipescu, Geneviève Almouzni
      Pages 385-419
    4. Nuphar Salts, Eran Meshorer
      Pages 421-448
    5. Sanaa Choufani, Rosanna Weksberg
      Pages 449-465
  9. Transcription and RNA Metabolism

    1. Front Matter
      Pages 467-467
    2. Christopher Eskiw, Jenifer Mitchell
      Pages 469-489
    3. Jonathan Sheinberger, Yaron Shav-Tal
      Pages 491-513

About this book


This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.


Chromosomes Epigenetics Nuclear function Nuclear regulation Nuclear structure Nucleus

Editors and affiliations

  • David P. Bazett-Jones
    • 1
  • Graham Dellaire
    • 2
  1. 1.Genetics and Genome BiologyThe Hospital for Sick ChildrenTorontoCanada
  2. 2.Dalhousie UniversityHalifaxCanada

Bibliographic information