Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds

  • Stacey L. McDonald

Part of the Springer Theses book series (Springer Theses)

About this book


This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 


Electrophilic Amination Aryl Amines Copper-Catalyzed Amination C–H Functionalization C–N Bond Formation Alpha-Aminophosphonic Acids

Authors and affiliations

  • Stacey L. McDonald
    • 1
  1. 1.Dept. of ChemistryDuke University Dept. of ChemistryDurham, NCUSA

Bibliographic information