Host Defense Peptides and Their Potential as Therapeutic Agents

  • Richard M. Epand

Table of contents

  1. Front Matter
    Pages i-x
  2. Biological Targets of Host Defense Peptides

    1. Front Matter
      Pages 1-1
    2. Monique L. van Hoek
      Pages 3-26
    3. Karl Lohner, Regina Leber
      Pages 27-55
    4. Filipa Henderson Sousa, Victor Casanova, Craig Stevens, Peter G. Barlow
      Pages 57-94
    5. Diana Gaspar, Miguel A.R.B. Castanho
      Pages 95-109
    6. Ravinder K. Goyal, Autar K. Mattoo
      Pages 111-136
  3. Immune Modulation by Host Defense Peptides

    1. Front Matter
      Pages 137-137
    2. Min Wan, Xiao Tang, Jesper Z. Haeggström
      Pages 139-158
  4. Development of Resistance

    1. Front Matter
      Pages 159-159
    2. David A. Phoenix, Sarah R. Dennison, Frederick Harris
      Pages 161-204
  5. Recent Advances in Engineering Host Defense Peptides

    1. Front Matter
      Pages 227-227
    2. Stephanie Deshayes, Michelle W. Lee, Nathan W. Schmidt, Wujing Xian, Andrea Kasko, Gerard C. L. Wong
      Pages 253-290
  6. Therapeutic Perspectives

    1. Front Matter
      Pages 291-291
    2. Catherine P James, Mona Bajaj-Elliott
      Pages 293-299
    3. Sarah C. Mansour, Robert E.W. Hancock, Michael Otto
      Pages 301-321

About this book


This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this. The chapters, written by leading experts in the field, detail the number and diversity of host defense peptides, and discuss the therapeutic potential not only of antibacterial, but also of antifungal, antiviral, plant antimicrobial and anticancer host defense peptides. The authors provide new insights into their mechanisms of action and their immunomodulatory properties, and review recent advances in the design of novel therapeutic molecules. Lastly, their potential to prevent preterm births and Staphylococcus aureus infections is highlighted. The book is of interest to researchers, industry and clinicians alike.


Drug discovery Innate immunity Peptide engineering Therapeutic applications Antibiotics Immunomodulation Innate immune response Antibacterial host defense peptides Antifungal host defense peptides Antiviral host defense peptides Anticancer host defense peptides

Editors and affiliations

  • Richard M. Epand
    • 1
  1. 1.Health Sciences CentreMcMaster UniversityHamiltonCanada

Bibliographic information