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Protein Targeting Compounds

Prediction, Selection and Activity of Specific Inhibitors

  • Thomas Böldicke

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 917)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Methods of Structure Prediction

    1. Front Matter
      Pages 1-1
  3. Antibodies

    1. Front Matter
      Pages 9-9
    2. Katja Hanack, Katrin Messerschmidt, Martin Listek
      Pages 11-22
    3. Florian Tomszak, Susanne Weber, Jonas Zantow, Thomas Schirrmann, Michael Hust, André Frenzel
      Pages 23-54
    4. Tobias Unkauf, Sebastian Miethe, Viola Fühner, Thomas Schirrmann, André Frenzel, Michael Hust
      Pages 55-76
    5. Andrea L. J. Marschall, Stefan Dübel, Thomas Böldicke
      Pages 77-93
    6. Martin Gasser, Ana Maria Waaga-Gasser
      Pages 95-120
  4. Peptides, Small Molecules and Aptamers

    1. Front Matter
      Pages 145-145
    2. Dorothea Helmer, Katja Schmitz
      Pages 147-183
    3. Miriam Fontanillo, Maja Köhn
      Pages 209-240
    4. Meltem Avci-Adali
      Pages 241-258
  5. Angiogenesis Inhibitors

    1. Front Matter
      Pages 259-259
    2. H. Büning, U. T. Hacker
      Pages 261-285
  6. Back Matter
    Pages 287-288

About this book

Introduction

This book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions.

Key aspects of this book are:

- Selection strategies for monoclonal and recombinant human antibodies

- Selection strategies for ER intrabodies, peptides and aptamers

- Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology

- Antibodies for cancer therapy and inhibitors of angiogenesis.

The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology. The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions.

Keywords

Allosteric Modulators Aptamers Peptides Phosphatases Recombinant antibodies

Editors and affiliations

  • Thomas Böldicke
    • 1
  1. 1.Recombinant protein exprsn/Intrabdy unitHelmholtz-Centre for Infection ReseBraunschweigGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-32805-8
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-32804-1
  • Online ISBN 978-3-319-32805-8
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site