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Cardiomyocytes – Active Players in Cardiac Disease

  • Klaus-Dieter Schlüter

Table of contents

  1. Front Matter
    Pages i-xv
  2. Cardiomyocytes: Function and Regeneration

    1. Front Matter
      Pages 1-1
    2. Klaus-Dieter Schlüter
      Pages 3-23
    3. Marten Szibor
      Pages 25-65
    4. Susanne Rohrbach, Bernd Niemann
      Pages 97-134
  3. Cardiomyocytes in Ageing, Disease, and Protection

    1. Front Matter
      Pages 165-165
    2. Jacqueline Heger
      Pages 223-245
    3. Gerhild Euler
      Pages 247-265
    4. Rainer Schulz, Fabio Di Lisa
      Pages 267-278

About this book

Introduction

This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine.

The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology.

Keywords

cardiac protection cardiac remodelling hypertrophy self renewing capacity excitation-contraction coupling

Editors and affiliations

  • Klaus-Dieter Schlüter
    • 1
  1. 1.Institute of PhysiologyJustus-Liebig-Universität GiessenGiessenGermany

Bibliographic information