Cancer and Zebrafish

Mechanisms, Techniques, and Models

  • David M. Langenau

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 916)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Powers of the Zebrafish Model

    1. Front Matter
      Pages 1-1
    2. Marie Mayrhofer, Marina Mione
      Pages 21-59
    3. John M. Parant, Jing-Ruey Joanna Yeh
      Pages 61-86
    4. Michelle Dang, Rachel Fogley, Leonard I. Zon
      Pages 103-124
    5. Richard M. White
      Pages 125-145
    6. Xiaoqian Huang, Ira Agrawal, Zhen Li, Weiling Zheng, Qingsong Lin, Zhiyuan Gong
      Pages 147-168
    7. Yelena Chernyavskaya, Brandon Kent, Kirsten C. Sadler
      Pages 169-197
    8. Jonathan W. Astin, Philip S. Crosier
      Pages 199-218
    9. Myron S. Ignatius, Madeline Hayes, David M. Langenau
      Pages 219-237
    10. C. Tulotta, S. He, W. van der Ent, L. Chen, A. Groenewoud, H. P. Spaink et al.
      Pages 239-263
    11. John C. Moore, David M. Langenau
      Pages 265-287
    12. Jaime Wertman, Chansey J. Veinotte, Graham Dellaire, Jason N. Berman
      Pages 289-314
    13. Wietske van der Ent, Wouter J. Veneman, Arwin Groenewoud, Lanpeng Chen, Claudia Tulotta, Pancras C. W. Hogendoorn et al.
      Pages 315-332
  3. Cancer Models in Fish

    1. Front Matter
      Pages 333-333
    2. Nicholas R. Harrison, Fabrice J. F. Laroche, Alejandro Gutierrez, Hui Feng
      Pages 335-369
    3. Michael Phelps, Eleanor Chen
      Pages 371-389
    4. Viola H. Lobert, Dmitri Mouradov, Joan K. Heath
      Pages 411-437
    5. Charles K. Kaufman
      Pages 439-450
    6. Shizhen Zhu, A. Thomas Look
      Pages 451-478
    7. Angelica Sanchez, James F. Amatruda
      Pages 479-494
    8. Adam D. Durbin, Dong Hyuk Ki, Shuning He, A. Thomas Look
      Pages 495-530
    9. Manfred Schartl, Ronald B. Walter
      Pages 531-552

About this book


This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.


cancer models germ cell tumors oncogenes tumor suppressors xenograft transplantation

Editors and affiliations

  • David M. Langenau
    • 1
  1. 1.Molecular Pathology and Cancer CenterMassachusetts General HospitalCHARLESTOWNUSA

Bibliographic information