Applied Immunohistochemistry in the Evaluation of Skin Neoplasms

  • Jose A. Plaza
  • Victor G. Prieto

Table of contents

  1. Front Matter
    Pages i-ix
  2. Immunohistology of Epithelial Tumors

    1. Front Matter
      Pages 1-1
    2. Heather Froehlich, Jose A. Plaza
      Pages 3-24
  3. Adnexal Neoplasms

    1. Front Matter
      Pages 25-25
    2. Ana M. Molina-Ruiz, Laura Fuertes, Luis Requena
      Pages 27-57
    3. Olayemi Sokumbi, Jose A. Plaza
      Pages 59-80
  4. Immunohistology of Cutaneous Metastases and Its Simulators

    1. Front Matter
      Pages 101-101
    2. Danielle M. Wehle, Martin Sangueza, Sadia Salim
      Pages 103-115
  5. Immunohistology of Mesenchymal Neoplasms

    1. Front Matter
      Pages 117-117
    2. Danny Ghazarian, Sebastien Labonte, Brendan Craig Dickson, Ayman Al Habeeb
      Pages 119-143
  6. Immunohistology of Cutaneous Lymphoma

    1. Front Matter
      Pages 205-205
    2. Carlos A. Torres-Cabala, Phyu P. Aung, Roberto N. Miranda, Jonathan L. Curry
      Pages 229-259
    3. Maria Teresa Fernández Figueras, Gustavo Tapia, José Luis Mate, Aurelio Ariza
      Pages 261-308
  7. Immunohistology of Melanocytic Lesions

    1. Front Matter
      Pages 309-309
    2. Jonathan L. Curry, Michael T. Tetzlaff, Priyadharsini Nagarajan, Carlos A. Torres-Cabala
      Pages 311-334
  8. Molecular Studies of Melanocytic Lesions

    1. Front Matter
      Pages 335-335
    2. Rami Al-Rohil, Priyadharsini Nagarajan, Michael T. Tetzlaff
      Pages 337-364
  9. Immunohistology of Sentinel Lymph Node in Melanoma

    1. Front Matter
      Pages 365-365
    2. Victor G. Prieto
      Pages 367-374
  10. Back Matter
    Pages 375-385

About this book


This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. The book reviews in detail the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining. Readers will learn when to order antibodies and how to interpret findings. In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. The informative text is complemented by a wealth of superb images. Helpful histograms and algorithms are included, and clear guidance is provided on the application and interpretation of less commonly used antibodies and immunostains.

With the emergence of many immunomarkers, immunohistochemistry has become a vital ancillary diagnostic tool in dermatopathology and an essential adjunct for the correct identification of skin neoplasms. Indeed, immunohistochemistry has replaced simple morphologic evaluation as the definitive diagnostic method for various tumor types. The complexity of some skin neoplasms makes it imperative that the role of immunohistochemistry in subtyping these conditions is clearly understood. Against this background, Applied Immunohistochemistry in the Evaluation of Skin Neoplasms will serve as an extremely valuable resource for practicing dermatopathologists and pathologists.


Adnexal Neoplasms Cutaneous Lymphoma Melanocytic Lesions Neuroendocrine Carcinoma of the Skin Sentinel Lymph Node in Melanoma Tumors of the Surface Epithelium

Editors and affiliations

  • Jose A. Plaza
    • 1
  • Victor G. Prieto
    • 2
  1. 1.Miraca Life SciencesDermatopathology DivisionDallasUSA
  2. 2.Department of PathologyUniversity of Texas MD Anderson Cancer CenterHoustonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-30588-2
  • Online ISBN 978-3-319-30590-5
  • Buy this book on publisher's site