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Autophagy Networks in Inflammation

  • Maria Chiara Maiuri
  • Daniela De Stefano

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Molecular Mechanisms Underlying Autophagy in Inflammation

    1. Front Matter
      Pages 1-1
    2. Rosa A. González-Polo, Elisa Pizarro-Estrella, Sokhna M. S. Yakhine-Diop, Mario Rodríguez-Arribas, Rubén Gómez-Sánchez, Ignacio Casado-Naranjo et al.
      Pages 3-20
    3. Christophe Viret, Mathias Faure
      Pages 21-41
    4. Kelly Airiau, Mojgan Djavaheri-Mergny
      Pages 43-60
    5. Qiming Liang, Jianning Ge, Xi Jin
      Pages 61-79
    6. Johan Arnold, Diane Murera, Frédéric Gros
      Pages 107-133
    7. Eun-Kyeong Jo, Jin Kyung Kim, Seungmin Hwang
      Pages 135-153
    8. Christophe Macri, Justine D. Mintern
      Pages 155-170
    9. Alexander J. Clarke, A. Katharina Simon
      Pages 171-184
    10. Jin Wang, Min Chen
      Pages 185-199
  3. Targeting Autophagy as a Novel Therapeutic Strategy in Inflammation-Based Pathologies

    1. Front Matter
      Pages 201-201
    2. Annalisa Nobili, Virve Cavallucci, Marcello D’Amelio
      Pages 203-234
    3. Ferenc Sipos, Györgyi Műzes
      Pages 235-265
    4. Lorena García, Mario Bustamante, Marcela Pizarro, Clara Quiroga, Andrea E. Rodriguez, Francisco Westermeier et al.
      Pages 297-322
    5. Eugenia Morselli, Alfredo Criollo
      Pages 323-343
    6. Valentina Sica, Valentina Izzo
      Pages 345-364
    7. Emanuela Esposito, Michela Campolo, Marika Cordaro, Giovanna Casili, Salvatore Cuzzocrea
      Pages 365-394
  4. Back Matter
    Pages 395-403

About this book

Introduction

Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.

Keywords

autoimmune diseases autophagy inflammation-based diseases molecular mechanisms therapeutic approaches

Editors and affiliations

  • Maria Chiara Maiuri
    • 1
  • Daniela De Stefano
    • 2
  1. 1.Centre de Recherche des CordeliersUMRS 1138 – Team 11,ParisFrance
  2. 2.Multi Medica Fondazione OnlusMilanItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-30079-5
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-30077-1
  • Online ISBN 978-3-319-30079-5
  • Buy this book on publisher's site