Vascular Ion Channels in Physiology and Disease

  • Irena Levitan, PhD
  • Alex M. Dopico, MD, PhD

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Ion Channel Regulation of Vascular Tone and Blood Flow. Changes with Hypertension: Endothelial Cells

  3. Ion Channel Regulation of Vascular Tone and Blood Flow. Changes with Hypertension: Smooth Muscle Cell

    1. Front Matter
      Pages 129-129
    2. Michael A. Hill, Yan Yang, Zahra Nourian, Barry D. Kyle, Kwangseok Hong, Andrew P. Braun
      Pages 131-152
    3. M. Dennis Leo, Jonathan H. Jaggar
      Pages 153-168
    4. Anup K. Srivastava, Lee Ann MacMillan-Crow, Sung W. Rhee, Nancy J. Rusch
      Pages 169-190
    5. Bharath K. Mani, Lyubov I. Brueggemann, Sarkis Morales-Vidal, Christopher M. Loftus, Kenneth L. Byron
      Pages 191-214
  4. Ion Channels in the Regulation of Cell Proliferation, Remodeling, Hypertrophy and Angiogenesis

    1. Front Matter
      Pages 231-231
    2. John G. McCarron, Susan Chalmers, Calum Wilson, Mairi E. Sandison
      Pages 233-254 Open Access
    3. Holly C. Cappelli, Roslin J. Thoppil, Ravi K. Adapala, J. Gary Meszaros, Sailaja Paruchuri, Charles K. Thodeti
      Pages 255-273
    4. David J. Beech, Jing Li, Lynn McKeown, Hollie L. Appleby
      Pages 275-294
    5. Ramon J. Ayon, Haiyang Tang, Ruby A. Fernandez, Ayako Makino, Jason X.-J. Yuan
      Pages 295-324
  5. Ion Channel Regulation by Lipids and Channel Modifications in Metabolic Disease

    1. Front Matter
      Pages 325-325
    2. Alex M. Dopico, Anna N. Bukiya, Guruprasad Kuntamallappanavar
      Pages 349-380
    3. Stacey L. Dineen, Zachary P. Neeb, Alexander G. Obukhov, Michael Sturek
      Pages 381-396
    4. Aaron H. Truong, Saravanakumar Murugesan, Katia D. Youssef, Ayako Makino
      Pages 397-419
  6. John G. McCarron, Susan Chalmers, Calum Wilson, Mairi E. Sandison
    Pages E1-E1
  7. Back Matter
    Pages 421-431

About this book


Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions.  Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.


ion channels proteins transport endothelium calcium ions potassium

Editors and affiliations

  • Irena Levitan, PhD
    • 1
  • Alex M. Dopico, MD, PhD
    • 2
  1. 1.University of Illinois at ChicagoChicagoUSA
  2. 2.The University of TennesseeMemphisUSA

Bibliographic information