Radiobiology of Glioblastoma

Recent Advances and Related Pathobiology

  • Luigi Pirtoli
  • Giovanni Luca Gravina
  • Antonio Giordano

Part of the Current Clinical Pathology book series (CCPATH)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano
    Pages 1-11
  3. From Bedside to Bench: Radiobiological Topics Arising from Clinical Studies

    1. Front Matter
      Pages 13-13
    2. Michela Buglione, Luca Triggiani, Paolo Borghetti, Sara Pedretti, Nadia Pasinetti, Stefano Maria Magrini
      Pages 15-27
    3. Silvia Scoccianti, Riccardo Santoni, Beatrice Detti, Gianluca Ingrosso, Daniela Greto, Giulio Francolini
      Pages 29-40
    4. Silvia Chiesa, Mario Balducci, Milena Ferro, Anna Rita Alitto, Vincenzo Valentini
      Pages 41-62
    5. Walter Tinganelli, Marco Durante, Alexander Helm
      Pages 63-85
    6. Piernicola Pedicini, Lidia Strigari, Luigi Spiazzi, Alba Fiorentino, Paolo Tini, Luigi Pirtoli
      Pages 87-100
    7. Paolo Tini, Clelia Miracco, Marzia Toscano, Silvia Palumbo, Sergio Comincini, Giovanni Luca Gravina et al.
      Pages 101-120
    8. Francesca De Felice, Vincenzo Tombolini, Michela Buglione, Daniela Musio, Luca Triggiani, Stefano Maria Magrini
      Pages 121-135
  4. Preclinical Research

    1. Front Matter
      Pages 139-139
    2. Monica Mangoni, Mariangela Sottili, Chiara Gerini, Lorenzo Livi
      Pages 139-153
    3. Benjamin Cooper, Ralph Vatner, Encouse Golden, Joshua Silverman, Silvia Formenti
      Pages 155-175
    4. A. Cimini, A. Fidoamore, M. d’Angelo, A. Antonosante, L. Cristiano, E. Benedetti et al.
      Pages 177-187
    5. Mariangela Sottili, Chiara Gerini, Isacco Desideri, Mauro Loi, Lorenzo Livi, Monica Mangoni
      Pages 189-207
    6. Marzia Toscano, Silvia Palumbo, Paolo Tini, Clelia Miracco, Giovanni Luca Gravina, Sergio Comincini
      Pages 209-224
    7. Silvia Palumbo, G. Belmonte, Paolo Tini, Marzia Toscano, Clelia Miracco, Sergio Comincini
      Pages 225-237
    8. Elisa Panzarini, Luciana Dini
      Pages 239-252
  5. From Bench to Bedside: Translational Perspectives

    1. Front Matter
      Pages 253-253
    2. Anita Tandle, Uma Shankavaram, Cody Schlaff, Kevin Camphausen, Andra Krauze
      Pages 255-274
    3. Nadia Pasinetti, Luigi Pirtoli, Michela Buglione, Luca Triggiani, Paolo Borghetti, Paolo Tini et al.
      Pages 275-292
    4. Elisa Meldolesi, Mario Balducci, Silvia Chiesa, Andrea Damiani, Nicola Dinapoli, Roberto Gatta et al.
      Pages 293-302
    5. Antonio Giordano, Giovanni Luca Gravina, Luigi Pirtoli
      Pages 303-305

About this book


This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. 

Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators. 


Particle Radiation Therapy Radiobiological Parameters Tumor Initiation Tumor Microenvironment Gene Therapy

Editors and affiliations

  • Luigi Pirtoli
    • 1
  • Giovanni Luca Gravina
    • 2
  • Antonio Giordano
    • 3
  1. 1.University of SienaSec. of Radiation Oncology,Dept. of Med.SienaItaly
  2. 2.Dept. of Applied Clinical & Biotech Sci.University of L’AquilaL’AquilaItaly
  3. 3.Department of BiologyTemple UniversityPhiladelphiaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-28303-6
  • Online ISBN 978-3-319-28305-0
  • Series Print ISSN 2197-781X
  • Series Online ISSN 2197-7828
  • Buy this book on publisher's site