Translational Toxicology

Defining a New Therapeutic Discipline

  • Claude L. Hughes
  • Michael D. Waters

Part of the Molecular and Integrative Toxicology book series (MOLECUL)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Claude L. Hughes, Michael D. Waters, David Allen, Iyabo Obasanjo
      Pages 3-44
  3. Toxicant Modes of Action and Biomarkers

    1. Front Matter
      Pages 83-83
    2. Edward L. Croom
      Pages 85-111
    3. Rais Ansari, Claude L. Hughes, Kazim Husain
      Pages 113-137
    4. David A. Skaar, Susan K. Murphy, Cathrine Hoyo
      Pages 139-169
    5. Elena Demicheva, Fatima Crispi
      Pages 171-212
  4. Developmental Risks of Exposures and Potential Translational Toxicology Therapeutics

    1. Front Matter
      Pages 213-213
    2. M. A. Dominguez, J. C. Sadeu, M. T. Guerra, H. C. Furlong, Sharnjit Baines, Warren G. Foster
      Pages 215-244
    3. Kelly K. Ferguson, John D. Meeker
      Pages 269-293
    4. Roseane Maria M. Santos, Darcy Roberto A. Lima
      Pages 321-337
  5. Back Matter
    Pages 373-380

About this book


Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice.

Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.


biomarker endocrine disruptor environmental exposure susceptability therapeutic intervention

Editors and affiliations

  • Claude L. Hughes
    • 1
  • Michael D. Waters
    • 2
  1. 1.Therapeutic Science & Strategy UnitQuintiles Inc.MORRISVILLEUSA
  2. 2.Michael Waters ConsultingHillsboroughUSA

Bibliographic information