Calcium Entry Pathways in Non-excitable Cells

  • Juan A. Rosado

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 898)

Table of contents

  1. Front Matter
    Pages i-x
  2. Store-Operated Calcium Entry

    1. Front Matter
      Pages 1-1
    2. Letizia Albarran, Jose J. Lopez, Ginés M. Salido, Juan A. Rosado
      Pages 3-24
    3. Irene Frischauf, Marc Fahrner, Isaac Jardín, Christoph Romanin
      Pages 25-46
    4. Dong Min Shin, Aran Son, Seonghee Park, Min Seuk Kim, Malini Ahuja, Shmuel Muallem
      Pages 47-66
    5. Alan G. S. Harper, Stewart O. Sage
      Pages 67-85
    6. Hwei Ling Ong, Lorena Brito de Souza, Indu S. Ambudkar
      Pages 87-109
    7. Tarik Smani, Alejandro Domínguez-Rodriguez, Paula Callejo-García, Juan A. Rosado, Javier Avila-Medina
      Pages 111-131
    8. Alejandro Berna-Erro, Isaac Jardín, Tarik Smani, Juan A. Rosado
      Pages 157-181
  3. Non-capacitative Ca2+ Entry Pathways

    1. Front Matter
      Pages 183-183
    2. Guillermo Vazquez, Sumeet Solanki, Prabhatachandra Dube, Kathryn Smedlund, Prince Ampem
      Pages 185-199
    3. Alexandre Bouron, Sylvain Chauvet, Stuart Dryer, Juan A. Rosado
      Pages 201-249
    4. Xuexin Zhang, Amy M. Spinelli, Timothy Masiello, Mohamed Trebak
      Pages 251-264
    5. Francisco J. Taberner, Isabel Devesa, Antonio Ferrer-Montiel
      Pages 265-304
  4. Role of Cellular Microdomains and Organelles in Calcium Entry

    1. Front Matter
      Pages 331-331
    2. Ziane Elaib, Francois Saller, Regis Bobe
      Pages 333-352
    3. Jonathan Pacheco, Josué O. Ramírez-Jarquín, Luis Vaca
      Pages 353-378
    4. Rosalba Fonteriz, Jessica Matesanz-Isabel, Jessica Arias-del-Val, Pilar Alvarez-Illera, Mayte Montero, Javier Alvarez
      Pages 405-421
    5. G. Cristina Brailoiu, Eugen Brailoiu
      Pages 423-447
    6. Carlos Villalobos, Diego Sobradillo, Miriam Hernández-Morales, Lucía Núñez
      Pages 449-466
  5. Back Matter
    Pages 467-471

About this book


Calcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating the calcium entry process. Particular attention is given to the fascinating group of ion channels involved in different calcium entry pathways as well as the emerging role of these channels in human disease. Calcium entry is an essential mechanism for cellular function in non-excitable cells. In general, two main calcium entry pathways exist in non-excitable cells: one pathway, named store-operated calcium entry (SOCE) requires store depletion and the second pathway is regulated by receptor occupation, but independently on calcium store depletion. The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channels as the calcium-permeable channels located in the plasma membrane. The location, interactions and function of these channels are finely regulated by a number of scaffolding proteins, membrane microdomains and cellular organelles that fine tune the amount of calcium entering the cell. Cutting-edge and user-friendly, this volume presents relevant background information, critical analysis of the current observations and directions for future research. The book is intended for basic scientists specializing in cellular biology or ion transport, as well as for biomedical researchers.


STIM1 Orai1 TRP channels Calcium entry Cellular microdomains

Editors and affiliations

  • Juan A. Rosado
    • 1
  1. 1.Depto. FisiologíaUniversity of ExtremaduraCáceresSpain

Bibliographic information