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Myeloid-Derived Suppressor Cells and Cancer

  • David Escors
  • James E. Talmadge
  • Karine Breckpot
  • Jo A. Van Ginderachter
  • Grazyna Kochan

Part of the SpringerBriefs in Immunology book series (BRIEFSIMMUN)

Table of contents

  1. Front Matter
    Pages i-ix
  2. James E. Talmadge
    Pages 1-24
  3. Grazyna Kochan
    Pages 39-48
  4. David Escors, Grazyna Kochan
    Pages 49-59
  5. David Escors, Grazyna Kochan
    Pages 91-102

About this book

Introduction

The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

Keywords

Ex vivo MDSC Differentiation STAT3 Pathway Human and Mouse MDSCs Murine MDSC Differentiation Myeloid-Derived Suppressor Cells (MDSCs) Therapeutic Targeting

Authors and affiliations

  • David Escors
    • 1
  • James E. Talmadge
    • 2
  • Karine Breckpot
    • 3
  • Jo A. Van Ginderachter
    • 4
  • Grazyna Kochan
    • 5
  1. 1.Fundación Miguel Servet, IdiSNANavarrabiomed-Biomedical Research CentrePamplonaSpain
  2. 2.Dept. of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOMAHAUSA
  3. 3.Faculty of Medicine and PharmacyVrije Universiteit BrusselBrusselBelgium
  4. 4.VIB Lab Myeloid Cell Immun, BLDG. EVrije Universiteit BrusselBrusselsBelgium
  5. 5.Fundación Miguel Servet, IdiSNANavarrabiomed-Biomedical Research CentrePamplonaSpain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-26821-7
  • Copyright Information The Author(s) 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-26819-4
  • Online ISBN 978-3-319-26821-7
  • Series Print ISSN 2194-2773
  • Series Online ISSN 2194-2781
  • Buy this book on publisher's site